Highly thermal conductive grease composition and cooling device using the same

ABSTRACT

There are provided a highly thermal conductive grease composition having both a thermal conductivity and a satisfactory dispense property, and a cooling device applied with same. The grease composition comprises from 70 to 90% by volume of an inorganic powder which is a mixture containing at least two kinds of inorganic powders different from each other in each average particle size, and from 10 to 30% by volume of a base oil containing a mineral oil or a synthetic oil, the base oil further containing a surfactant in an amount of from 0.2 to 2.0% by weight based on the weight of the inorganic powder.

FIELD OF THE INVENTION

[0001] The present invention relates to a thermal conductive material applied between an exothermic portion and a cooling portion in electric and electronic apparatus etc. More specifically, the present invention relates to a highly thermal conductive grease composition comprising an inorganic powder and a cooling device applied with same.

BACKGROUND OF THE INVENTION

[0002] Efficiency of a cooling device used for removing heat generated by an integrated circuit element greatly depends upon a thermal conductivity, i.e. a thermal resistance, of a thermal conductive grease which is called also a thermal conductive compound and which is filled in a contact surface between an exothermic surface and a radiating portion in the integrated circuit element. As a material used for the thermal conductive grease composition for the integrated circuit element, there is used a material that is possessed of an electrical insulation and that is capable of quickly removing the generated heat through a radiating portion, because the grease composition is brought into indirect or direct contact with both the integrated circuit element and the radiating surface.

[0003] As the thermal conductive grease, there are so far known those comprising a base oil including a silicone oil such as polydimethylsiloxane and polymethylphenysiloxane and a heat transfer substance including a powder such as aluminum nitride, silica, alumina, metal silicon, boron nitride and zinc oxide (cf. JP-A 51-55870, JP-B 52-33272, JP-A 54-116055, JP-A 55-45770, JP-A 61-157587, JP-A 2-153995, JP-A 2-212556, JP-A 3-14873, JP-A 3-162493, Japanese Patent No. 2925721, Japanese Patent No. 2938429, and JP-A 2000-109373).

[0004] Japanese Patent No. 2930298 discloses a thermal conductive grease composition comprising an aluminum nitride powder which is surface-treated with an organosilane and/or a partially hydrolyzed condensate thereof and a base oil of a liquid hydrocarbon oil or a fluorohydrocarbon oil. However, the thermal conductivity thereof is about 2.3 W/m·K, which is not satisfactory.

[0005] Japanese Patent No. 2938429 discloses a thermal conductive silicone composition comprising a silicone oil and thermal conductive inorganic fillers different from each other in each Moh's hardness. However, the thermal conductivity thereof is also from 2.72 to 3.97 W/m·K, which is not sufficiently satisfactory.

[0006] For the purpose of preventing isolation and bleeding of the silicon oil, JP-B 57-36302 discloses a thixotropic thermal conductive material prepared using a silica fiber, a dendrite like zinc oxide, a laminal aluminum nitride and a laminal boron nitride.

[0007] Further, there are disclosed a thermal conductive grease comprising perfluoro polyether as the base oil in JP-A 63-251455 and JP-A 3-106996, which is proposed mainly to improve a contact default, some grease blended with a urea compound in JP-A 4-117482, some grease added with a fluoro-surfactant in JP-A 63-57693 and JP-A 4-239597, which are proposed to prevent isolation and bleeding of the oil, and some grease prepared using a fluorine compound having a polyfluoroalkyl group and at least one oxyalkylene group in JP-A 10-140173. However, the thermal conductivity thereof is about 2.3 W/m·K, which is not satisfactory from a viewpoint of heat removal.

[0008] Japanese Patent No. 2938428 discloses some grease comprising a liquid hydrocarbon oil and/or a fluorohydrocarbon oil as the base oil and a combination of a specific thermal conductive inorganic filler having a thermal conductivity of not less than 100 W/m·K and another specific thermal conductive inorganic filler having a thermal conductivity of not less than 20 W/m·K, which are proposed to further improve a dispense property and a high thermal conductivity. The thermal conductivity of the grease disclosed is as remarkably good as from 2.59 to 4.02 W/m·K, and its dispense property is also good. A content of the base oil which is a liquid hydrocarbon oil and/or a fluorohydrocarbon oil used in these grease is found to be 10% by weight, which is calculated on the basis of the disclosure of Example. An oil-isolation degree measured at 150° C. for 24 hours according to JIS-K-2220 is found to be 0% by weight in every cases. Notwithstanding, a diffusion due to bleeding of the oil is caused when the grease is subjected to a heating test of 150° C./20 hours, in which the grease is coated on an aluminum nitride plate in a circular and gable roof form.

BRIEF SUMMARY OF THE INVENTION

[0009] It is an object of the present invention to provide a highly thermal conductive grease composition having both a high thermal conductivity and a satisfactory dispense property. It is another object of the present invention to provide a cooling device applied with same.

[0010] The present invention provides a highly thermal conductive grease composition which comprises an inorganic powder and a base oil containing a mineral oil or a synthetic oil, wherein the inorganic powder is a mixture of at least two kinds of inorganic powders different from each other in each average particle size, the base oil further contains a surfactant in an amount of from 0.2 to 2.0% by weight based on the weight of the inorganic powder, and a content of the base oil is from 10 to 30% by volume, and a content of the inorganic powder is from 70 to 90% by volume.

[0011] The present invention further provides a cooling device provided with an electric or electronic component assembled into an apparatus and a cooling body put on a surface of said component, in which the highly thermal conductive grease composition as above intervenes between said cooling body and a surface of an exothermic body in said component.

BRIEF DESCRIPTION OF THE DRAWINGS

[0012]FIG. 1 is a drawing to illustrate a method for testing diffusion of the base oil.

[0013]FIG. 2 is a drawing to show relations among a filler content of the inorganic powder and a thermal conductivity and liquation consistency of the grease.

[0014]FIG. 3 is a drawing to show a dispersion model of the inorganic powder in the case where a surfactant is added.

[0015]FIG. 4 is a drawing to show a dispersion model of the inorganic powder in the case where no surfactant is added.

[0016]FIG. 5 is a vertically sectional view of a cooling device applicable to electric and electronic apparatus.

[0017] Numerical marks are explained as follows;

[0018] 1: grease, 2: aluminum nitride plate, 3: portion of the base oil diffusion, 4: radiating body, 5: radiating plate, 6: exothermic body, 7: thermal conductive grease, 8: coarse particles and 9: fine particles.

DETAILED DESCRIPTION OF THE INVENTION

[0019] In the study of the prior arts, the thermal conductivity can be increased with an increase in a filler content of a thermal conductive inorganic filler, while the grease becomes hard (low consistency) to deteriorate its dispense property. In order to improve the dispense property, it is forced to lower a content of the thermal conductive powder, and as a result, a sufficient thermal conductivity cannot be obtained.

[0020] The dispense property is intended to mean a degree of workability on coating of grease such as, for example, spread on a surface to be coated, flow properties and adherability, and is related to hardness of the grease. In the case where the dispense property is insufficient, it may be made difficult to extrude the grease or coat the grease thinly using a filling machine provided with a syringe or a cylinder like coating means.

[0021] For that reason, the thermal conductive grease is required to attain a good dispense property and a high thermal conductivity at the same time. It is necessary therefor to study a filler content, shape and average particle size of the thermal conductive powder, a viscosity of the base oil, and a surfactant causing no decrease of the electrical resistance. Particularly, in order to realize miniaturization of a cooling structure and in order to apply to a cooling device used for electronic components which are high in an integration density and great in a calorific value, it is necessary to attain a high thermal conductivity and further improve bleeding and diffusion properties of the base oil.

[0022] With respect to a thermal conductive grease comprising a silicone oil as the base oil, the silicone oil is very low in its surface tension and its interfacial tension, and therefore there is a tendency such that an isolation of the base oil occurs to cause a decrease in thickness and volume of the grease, and as a result, shrinkage and cracking of the grease are produced. Therefore, it may happen that a void is formed between an exothermic surface and a radiating surface, so that a temperature of the exothermic portion rises.

[0023] Further, there is a possibility such that the base oil isolated from the grease or the silicone oil bled therefrom easily diffuse to stain the periphery or causes a formation of an insulating material such as silicon dioxide (SiO₂) and silicon carbide (SiC), and at last electric and electronic apparatus are put out of order, which insulating material can be produced from a low molecular weight siloxane which is contained in the silicone oil or which is produced by degradation of the silicone oil with the aid of spark heat at an electrical contact point.

[0024] For enabling electric and electronic components to suitably function, which components are assembled into electric and electronic apparatus, respectively, it is necessary that a thermal conductive grease to be filled in or coated to a contact surface between an exothermic portion and cooling portion of the components is high in its thermal conductivity and its electrical insulation, satisfactory in its dispense property and moreover free from an isolation and a diffusion of the base oil. For the purpose of obtaining such a high performance thermal conductive grease, the present inventors have undertaken extensive studies about a base oil which is a constituting material of the grease and its viscosity, a particle size of a thermal conductive inorganic powder, a blending proportion of coarse particles and fine particles present in the powder, a filler content thereof, and a surfactant exhibiting a satisfactory addition effect without great detriment to decrease in electrical resistance. As a result, the present inventors have found the facts that;

[0025] (1) with respect to the thermal conductive inorganic powder, the filler content thereof can be increased with decrease in the viscosity of the base oil,

[0026] (2) the thermal conductivity varies depending upon the particle size of a crystalline thermal conductive material rather than the kind and powder form thereof, and the larger the particle size, the higher the thermal conductivity, and

[0027] (3) a specific nonionic surfactant is added to the base oil effectively to increase the filler content of the thermal conductive inorganic powder, to increase a consistency and moreover to control and prevent isolation and diffusion of the base oil, and thereby the present invention was accomplished.

[0028] In accomplishing the foregoing objects, there is provided according to the present invention a highly thermal conductive grease composition, which comprises from 70 to 90% by volume of an inorganic powder containing a mixture of at least two kinds of inorganic powders different from each other in each average particle size, and from 10 to 30% by volume of a base oil containing a mineral oil or a synthetic oil, provided that the base oil further contains a surfactant in an amount of from 0.2 to 2.0% by weight based on the weight of the inorganic powder.

[0029] With respect to such a highly thermal conductive grease composition, a mutual contact area of the particles present in the grease is increased, so that the thermal conductivity is increased and at the same time the liquation consistency is improved to reach from 200 to 400, in other words, the grease composition becomes soft to be improved in its dispense property.

[0030] When such a highly thermal conductive grease composition is applied between the surface of an exothermic body and a cooling body of electric and electronic components, generated heat of the electric and electronic components can be effectively removed, and as a result, reliability of the components for electric and electronic apparatus can be improved and a cooling device can be made compact. In addition, since such a highly thermal conductive grease composition is free from an isolation and diffusion of the base oil and moreover possessed of an appropriate viscosity, it can be utilized as an adhesive agent when the electric and electronic components are assembled into electric and electronic apparatus, respectively, so that the production of electric and electronic apparatus can be facilitated.

[0031] Viscosity of the base oil used in the present invention is preferably from 15 to 450 mm²/s at 40° C. Examples of the base oil are α-olefin oligomers, diesters, polyol esters, trimellitic acid esters, polypheny ethers and alkyl phenyl ethers, which may be used singly or in combination of two or more.

[0032] The inorganic powder used in the present invention is preferably a combination of 40 to 90% by volume of coarse particles having an average particle size of from 5 to 17 μm, and 10 to 60% by volume of fine particles having an average particle size of from one third to one fortieth of that of the coarse particles. Examples of the inorganic powder are zinc oxide, magnesium oxide, titanium oxide, aluminum nitride, aluminum oxide and boron nitride, which may be used singly or in combination of two or more. Electrical characteristics of the inorganic powder can be selected depending on utilities of the highly thermal conductive grease composition, and the inorganic powder can be selected from conductors, semiconductors, insulators and dielectrics.

[0033] The surfactant used in the present invention is preferably a nonionic surfactant, particularly that having an HLB value of not more than 9.

PREFERRED EMBODIMENTS OF THE INVENTION

[0034] Kind of Base Oil

[0035] The base oil used in the present invention is a single or mixed oil, which is at least one member selected from mineral oils and synthetic oils. A particularly preferred synthetic oil is a hydrocarbon oil. Examples thereof to be used are α-olefin oligomers; diesters including dibasic acid esters obtained from alcohols and dibasic acids; polyol esters including polyol esters obtained from a polyhydroxyl alcohol having a carbon skeleton of neopentane and a fatty acid having 5 to 18 carbon atoms, or complex type polyol esters obtained from a mixed acid of aliphatic mono- and di-carboxylic acids having 4 to 10 carbon atoms and a polyhydroxyl alcohol of trimethylolpropane, pentaerythritol or dipentaerythritol; trimellitic acid esters, polyphenyl ethers; and alkyl phenyl ethers.

[0036] When it is not required to control and prevent an isolation and diffusion of the base oil, it is permitted to use a liquid silicone such as a methyl type silicone oil and a phenyl type silicone oil, and a fuluorohydrocarbon oil such as chlorofluorocarbon and perfluoro polyethers.

[0037] Viscosity of Base Oil

[0038] Viscosity of the base oil is preferably from b 15 to 450 mm²/sec. When the viscosity is less than 15 mm²/sec, it may happen that an evaporation loss is increased, so that a grease layer coated becomes thin because of a decrease of an oil content due to an evaporation of the oil, thereby forming an air layer at a contact surface or causing a crack formation, and as a result, the thermal conductivity is decreased. Whereas, when the viscosity exceeds 450 mm²/sec, it may happen that it is difficult to fill a large amount of the thermal conductive filler, so that a high conductivity cannot be obtained and at the same time a dispense property is deteriorated.

[0039] A content of the base oil is preferably from 10 to 30% by volume. The base oil content can be decreased with a decrease in the base oil viscosity, so that the inorganic powder content can be increased. However, when the base oil content is less than 10% by volume, it is apt to remarkably deteriorate the flow properties, adherability and dispense property, because the grease becomes hard. When the base oil content exceeds 30% by volume, the grease becomes remarkably soft to attain a satisfactory dispense property, but there is an unpreferable tendency such that a high thermal conductivity is hardly obtained and an isolation and diffusion of the base oil are caused.

[0040] Kind of Inorganic Powder

[0041] The inorganic powder includes those having a thermal conductivity to effectively transfer heat generated from the electric and electronic components. Examples thereof are metal oxides such as zinc oxide, magnesium oxide, titanium oxide and aluminum oxide; aluminum nitride; boron nitride; silicon carbide; silicon nitride; titanium nitride; metallic silicon and diamond, which may be used singly or in combination of two or more. The inorganic powder used is not limited thereto. The thermal conductivity of the grease greatly depends on the particle size of the thermal conductive inorganic powder rather than the thermal conductivity of the inorganic powder itself. Electrical characteristics of the inorganic powder may be selected depending on utilities of the grease. For example, when the grease is used for electronic components, an electrical insulating inorganic powder is usnally used. When the electrical insulation is not required, it is permitted to use various kinds of metal powders.

[0042] Combination of Particle Size

[0043] With respect to the inorganic powder, coarse particles and fine particles different from each other in each average particle size and each particle distribution are combined in the optimum proportion, thereby to be able to form a close-packed structure. In the close-packed structure, voids among the coarse particles are closely buried with the fine particles and a mutual contact surface of the particles is large, and as a result, the thermal resistance among particles can be remarkably reduced to attain a high thermal conductivity of the grease.

[0044] It is preferable to use an inorganic powder which is a combination of coarse particles having an average particle size of from 5 to 17 μm and fine particles having an average particle size of from one third to one fortieth of that of the coarse particles. A preferred blending proportion of the coarse particles and the fine particles is within a range of from 90 to 40% by volume of the coarse particles:from 10 to 60% by volume of the fine particles. A more preferred proportion is from 80 to 60% by volume of the coarse particles:from 20 to 40% by volume of the fine particles. When the blending proportion of the coarse particles and the fine particles deviates from the range of from 90 to 40% by volume of the coarse particles:from 10 to 60% by volume of the fine particles, it is apt to fail to obtain a good close-packed structure, thereby decreasing the thermal conductivity.

[0045] In order to attain a high thermal conductivity, it is preferable to use a mixed powder in the blending proportion of from 90 to 40% by volume of the coarse particles from 10 to 60% by volume of the fine particles in a filler content of 70 to 90% by volume based on the volume of the whole grease. When the filler content is not less than 70% by volume, a thermal conductivity of not less than 3 W/m·K can be attained. When the filler content is less than 70% by volume, it may happen that a satisfactory thermal conductivity is not obtained. Whereas, when it exceeds 90% by volume, it may happen that no grease formation can be attained.

[0046] Surfactant

[0047] A surfactant is added to the base oil, whereby a mutual contact surface area of the inorganic powder can be increased to decrease the thermal resistance among the inorganic particles, thereby increasing the thermal conductivity of the grease, and as a result, the filler content of the inorganic powder can be increased and a suitable consistency can be obtained to maintain a satisfactory dispense property, and moreover an isolation and diffusion of the base oil can be greatly improved. A nonionic surfactant is optimum in the case where it is required to hold an electrical insulation of the grease, because the nonionic surfactant does not affect the electrical characteristics of the grease.

[0048] Examples of the nonionic surfactant are polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene alkylnaphthyl ether, polyoxyethylene castor oil, polyoxyethylene hardened castor oil, polyoxyethylene alkylamide, polyoxyethylene-polyoxypropylene glycol, polyoxyethylene-polyoxypropylene glycol ethylenediamine, polyoxyethylene mono-fatty acid ester, polyoxyethylene di-fatty acid ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene sorbitan mono-fatty acid ester, polyoxyethylene sorbitane tri-fatty acid ester, ethylene glycol mono-fatty acid ester, diethylene glycol mono-fatty acid ester, propylene glycol mono-fatty acid ester, glycerol mono-fatty acid ester, pentaerythrit mono-fatty acid ester, sorbitan mono-fatty acid ester, sorbitan sesqui-fatty acid ester and sorbitan tri-fatty acid ester.

[0049] An addition effect of the nonionic surfactant varies depending upon the kind and amount of the thermal conductive filler and an HLB value showing balance of hydrophillic and lipophillic properties. In order to obtain the grease exhibiting a satisfactory dispense property even at room temperature, it is preferable to use a liquid nonionic surfactant having an HLB of not more than 9 as the nonionic surfactant to be used in the present invention. Such a surfactant is used in a blending amount of preferably from 0.2 to 2.0% by weight based on the filler weight of the thermal conductive filler powder. When the blending amount is less than 0.2% by weight, there is a tendency that the consistency is lowered, in other words, the grease becomes hard, thereby failing to obtain a satisfactory dispense property, and moreover the mutual contact state of the particles is deteriorated to cause decrease in the thermal conductivity. On the other hand, when the blending amount exceeds 2.0% by volume, there is a tendency that the grease obtained using a solid nonionic surfactant becomes hard. With respect to a liquid nonionic surfactant, there is a tendency that a much addition effect cannot be obtained.

[0050] In using the nonionic surfactant, the surfactant may be dissolved or emulsified in the base oil. Alternatively, the surfactant may be used in a manner such that the thermal conductive filler is previously surface-treated therewith, whereby a similar effect can be obtained.

[0051] In the uses where an electrical insulation of the grease or a decrease in the electrical resistance are not so important, it is permitted to use anionic surfactants, cationic surfactants and amphoteric surfactants as well as the nonionic surfactants.

[0052] Additives

[0053] In order to improve various properties of the highly thermal conductive grease composition in accordance with the present invention, which properties include, for example, oxidation-resisting property to prevent its oxidation degradation and metal corrosion-inhibiting property, various kinds of additives can be blended therewith. Examples of the additives to be blended are antioxidants such as amine-, phenol-, sulfur- and phosphorus-based compounds which are used for inhibiting oxidation degradation; corrosion inhibitors such as benztriazole and derivatives thereof; rust preventives such as carboxylic acids, carbonates and sulfonates; thickeners such as polybutene and polymethacrylates, which are used for further improving or bettering adherability of the grease and viscosity thereof; and thickening agent such as fatty acid salts and urea compounds.

[0054] A liquation consistency is preferably within a range of from 200 to 400 at 25° C. from a viewpoint of high thermal conductivity, dispense property, flow properties and adherability of the grease and moreover inhibition of the base oil isolation. Particularly hen the grease is applied to small-sized electronic components or fragile electronic components such as integrated circuit elements, more preferable is a liquation consistency of not less than 250.

[0055] Process for Producing Highly Thermal Conductive Grease Composition

[0056] The highly thermal conductive grease composition can be produced, for example, in the following manner.

[0057] The nonionic surfactant is dissolved in the base oil at room temperature or under heating, and thereafter a mixed powder prepared by blending the coarse particles and fine particles of the thermal conductive inorganic powder in a predetermined blending proportion is added thereto. The resulting mixture is pre-kneaded using a stirring rod or a stirring machine such as a planetary, a trimix and a twin-mixed mixer at room temperature or, if necessary, under heating. The pre-kneaded mixture is further kneaded under high shearing force to obtain a uniform product. Examples of a kneading machine are a three-roll and a colloid mill etc. It is preferred to carry out the kneading with the three-roll. The consistency and dispense property of the grease are sensitive to the kneading conditions such as kneading number of times and a distance between the rolls, and therefore it is necessary to study the optimum condition.

[0058] The highly thermal conductive grease composition of the present invention, which was obtained according to, for example, the above-mentioned process, can be used for utilities similar to those of a conventional thermal conductive grease composition. With respect to a cooling device in that the highly thermal conductive grease composition in accordance with the present invention intervenes between its exothermic portion and its cooling portion, thermal resistance can be remarkably decreased even when a contact surface of the grease is coarse, and as a result, stable radiation and heat diffusion can be attained to solve a miss action of electronic components, an operation suspension thereof or an accident thereto caused by accumulation of heat. Moreover, miniaturization of the cooling device and cost retrenchment can be attained.

[0059] The thermal conductive grease composition in accordance with the present invention can be applied to a contact surface between an exothermic body and a cooling body of electric and electronic components. For example, the grease can be applied to a cooling device in a power transistor, a power module, a transmission module, a rectifier and a semiconductor element of computer to improve performance of these apparatus. Further, when the grease intervenes between a thermistor or a thermo couple and a measuring portion, a satisfactory thermal conductivity can be attained to improve a measurement accuracy thereof.

[0060] The thermal conductive grease obtained in the following Examples was evaluated according to the test mentioned as follows.

[0061] 1. Measurement Method of Consistency

[0062] Measurement was carried out according to the method prescribed in JIS K 2220.5.3.4. The thermal conductive grease was allowed to stand for two days after the production, then transferred in a prescribed vessel without stirring, and kept at 25° C. Thereafter, the liquation consistency thereof was measured.

[0063] 2. Test Method of Base Oil Diffusion

[0064] The test method is as shown in FIG. 1. The grease was attached to the tip of an injector. About 0.2 g of the grease 1 was coated in a circular and gable room form on an aluminum nitride plate 2 (0.5 mm thick, 50×50 mm) having a surface coarseness (Ra) of 2 μm. The plate was fixed in a thermostat of 120° C. for 50 hours, and thereafter a diffusion width (mm) of the diffusion portion 3 of the bleeding base oil was calculated by the following equation (2).

Width of diffused oil=(diameter of bleeding−diameter of grease coated)/2  (2)

[0065] 3. Measurement Method of Thermal Conductivity

[0066] Thermal conductivity of the grease was measured according to a stationary method. That is, the sample was placed between a copper-made column like heating portion and a copper-made columnar cooling portion, and respective temperatures of the heating portion and the cooling portion were measured. The thermal conductivity of the sample placed between those was measured based on a temperature gradient, provided that respective temperatures were measured with a thermo couple buried in the heating portion and the cooling portion. Incidentally, the heat flow was determined from a temperature gradient and section area of the copper-made column. The thermal conductivity λ of the sample was calculated according to the following equation (3), provided that a high temperature end in the temperature of the heating portion and a low temperature end in the temperature of the cooling portion were assigned to be TH and TL, respectively.

λ={(QH+QL)/2×L}/A×(TH−TL)  (3)

[0067] QH:heat flow at high temperature side block (heating portion), QL:heat flow at low temperature side block (cooling portion), A:section area of contact portion of sample, L:thickness of sample, TH:temperature at high temperature side block, and TL:temperature at low temperature side block.

[0068] The thermal conductive grease composition in accordance with the present invention was obtained in the following manner. To a predetermined amount of a base oil in which a predetermined amount of a nonionic surfactant had been dissolved under heating, was added a predetermined amount of a mixed powder prepared by combining coarse particles and fine particles of a thermal conductive inorganic powder. The resulting mixture was stirred with a stirring rod at room temperature or under heating to 50 to 100° C. to finish a pre-kneading, followed by cooling to room temperature. The mixture pre-kneaded was kneaded five times using a three-roll milling machine, in which distances among the rolls were adjusted to a first stage: 150 μm and a second stage: 80 μm, respectively, thereby obtaining the desired thermal conductive grease composition.

EXAMPLES

[0069] The present invention is illustrated in more detail with reference to Examples, which are not to be construed as limiting the scope of the present invention.

Examples 1 to 10

[0070] The thermal conductive grease compositions were obtained using the materials mentioned below, provided that viscosity of the base oil and a filler content of the inorganic powder were varied, and then their thermal conductivity and liquation consistency were measured.

[0071] (1) Nonionic surfactant:decaglyceline fatty acid ester, i.e. decaglyceryl pentaoleate (Decaglyn 5-O (HLB: 3.5), manufactured by Nikko Chemicals Ltd.), 1% by weight based on the weight of the inorganic powder.

[0072] (2) Base oil:poly-α-olefin (SHF Series, manufactured by Mobil Chemical Co.), viscosity: 5.8 to 500 mm²/sec.

[0073] (3) Inorganic powder:zinc oxide powder, mixed powder prepared by combining coarse particles having an average particle size of 12.7 μm and fine particles having an average particle size of 0.76 μm, i.e. one seventeenth of that of the coarse particles in a blending proportion by volume of coarse particles 60:fine particles 40, filler content: 60 to 90% by volume.

[0074] With respect to the obtained thermal conductive grease compositions, their thermal conductivity and liquation consistency were measured. The results are as shown in Table 1. TABLE 1 Base oil (Sur- factant Exam- added) Thermal conductivity (W/m · K) Liquation consistency (at 25° C.) ple (mm²/s, Filler content of mixed powder (vol %) No. at 40° C.) 60 70 75 80 85 87 90 60 70 75 80 85 87 90 1 5.8 2.45 3.05 3.40 4.28 5.02 5.63 6.01 >420 >420 >420 400 340 311 290 2 8.8 2.30 3.07 3.39 4.21 5.07 5.65 6.02 >420 419 390 355 336 287 266 3 15.0 2.44 3.01 3.37 4.20 5.05 5.60 6.01 >420 410 387 348 310 276 244 4 30.0 2.31 3.12 3.27 4.10 4.95 5.41 400 375 359 312 252 218 5 47.0 2.34 3.16 3.28 3.99 5.01 5.35 385 370 349 269 247 210 6 68.0 2.31 3.16 3.27 4.05 4.98 5.36 378 347 323 251 236 200 7 209 2.20 3.20 3.47 4.05 4.95 5.40 360 320 289 245 224 155 8 400 2.26 3.25 3.45 3.99 4.99 5.35 350 315 255 240 210 142 9 450 2.18 3.20 3.48 Grease formation 328 243 205 Grease formation 10 500 2.37 3.12 3.27 impossible 302 227 175 impossible

[0075] As can be seen from the results of Examples 1 to 10, in some cases of combinations which are high in both the viscosity of the base oil and the filler content of the inorganic powder, no grease formation can be attained, but in the remaining cases where the desired grease formation can be attained, both the thermal conductivity and the liquation consistency can be increased with the aid of the nonionic surfactant of decaglyceryl pantaoleate. Thus, soft greases having a good thermal conductivity were obtained and they had a good dispense property.

[0076] Further in Examples 1 to 10, zinc oxide was used as the inorganic powder, and therefore the obtained thermal conductive grease is superior in its electrical insulation, so that the grease can be applied to components for electric and electronic apparatus.

[0077] In FIG. 2, there are shown relations among the filler content of the mixed powder, the thermal conductivity (3 W/m·K or more) and liquation consistency of the thermal conductive grease composition, when the viscosity of the base oil is within a range of from 15 mm²/sec to 450 mm^(2/)sec. As can be seen from said relations, almost regardless of the viscosity of the base oil, the thermal conductivity tends to be increased with increase in the filler content of the inorganic powder, allowing of some exception. On the other hand, the liquation consistency depends on the viscosity of the base oil. From Table 1 and FIG. 2, it is found that there can be obtained grease having a liquation consistency of from 200 to 400 and a thermal conductivity of 3 W/m·K or more, which conditions are to attain a satisfactory dispense property and a high thermal conductivity, when the filler content of the inorganic powder is not less than 70% by volume. In this case, the viscosity of the base oil may be within a range of from 15 to 450 mm²/sec. Furthermore, it was found that the filler content φ (% by volume) of the mixed powder and the viscosity η (mm²/sec) of the base oil at 40° C. can be expressed by the following expression (1).

Logφ≦−1×10⁻¹⁸×(η−250)⁵+1.9345   (1)

[0078] Furthermore, in a conventional grease, the liquation consistency is decreased with increase in the filler content of the inorganic powder, thereby resulting in a hard grease of an unsatisfactory dispense property. On the other hand, in Examples 1 to 10, the value of liquation consistency was not so largely decreased even if the filler content was increased.

Comparative Examples 1 to 10

[0079] For the comparison purpose with Examples 1 to 10, respective grease comprising 10 to 40% by volume of a poly-α-olefin base oil (SKF Series, manufactured by Mobil Chemical Company) were obtained with use of no nonionic surfantant. The results are shown in Table 2. TABLE 2 Com- Base oil parative (No sur- Exam- factant) Thermal conductivity (W/m · K) Liquation consistency (at 25° C.) ple (mm²/s, Filler content of mixed powder (vol %) No. at 40° C.) 60 70 80 85 87 90 60 70 80 85 87 90 1 5.8 1.14 Grease formation impossible 90 Grease formation impossible 2 8.8 1.18 87 3 18.0 1.12 85 4 30.0 1.76 84 5 47.0 1.79 81 6 68.0 1.88 86 7 209 1.87 73 8 400 1.66 1.34 75 25 9 450 1.60 1.42 64 36 10 500 1.54 1.46 64 42

[0080] As can be seen from the results of Comparative Examples 1 to 10, no grease formation can be attained in most of combinations, and even in some cases where the grease formation can be attained, both the thermal conductivity and the liquation consistency are lower than those of Examples 1 to 10, and neither a satisfactory dispense property nor a high thermal conductivity is attained.

Examples 11 to 23

[0081] Using materials mentioned below, thermal conductive grease compositions comprising 25% by volume of a base oil and 75% by volume of an inorganic powder were obtained, provided that a kind of the base oil was varied, and then the thermal conductivity, liquation consistency and diffusion width of the base oil caused by bleeding were measured. A mixing ratio of the mixed base oil was 50:50.

[0082] (1) Nonionic surfactant:decaglyceryl pentaoleate, 1% by weight based on the weight of the inorganic powder.

[0083] (2) Inorganic powder:zinc oxide powder, base oil:inorganic powder=25% by volume: 75% by volume, mixed powder prepared by combining coarse particles having an average particle size of 12.7 μm and fine particles having an average particle size of 0.76 μm, i.e. one seventeenth of that of the coarse particles in a blending proportion by volume of coarse particles 60:fine particles 40.

[0084] (3) Mineral oil:that manufactured by Cosmo Oil Lubricant Ltd.

[0085] (4) Synthetic oil:diester manufactured by Asahi Denka Ltd,

[0086] plyol ester manufactured by Asahi Denka Ltd.,

[0087] trimellitic acid ester manufactured by Asahi Denka Ltd.,

[0088] alkyl diphenyl ether manufactured by Matsumura Oil Research Corp.,

[0089] polyphenyl ether manufactured by Matsumura Oil Research Corp.,

[0090] polybutene manufactured by Nippon Mitsubishi Oil Corp., or

[0091] fluoro-oil manufactured by Ausimont Ltd.

[0092] Measurements results are as shown in Table 3. TABLE 3 Viscosity Thernal Exam- Base oil of base oil Liquation conduc- Diffusion ple (Surfactant (mm²/s, at consistency tivity width No. added) Product Name 40° C.) (at 25° C.) (W/m · K) (mm) 11 Mineral oil N-500 94 330 3.24 3.1 12 Diester Adekasin 2050 26 370 3.13 3.9 13 Poly-α-olefin SHC230 209 289 3.47 3.1 14 Polyol ester Blueper H-450 383 312 3.23 3.6 15 Trimellitic acid ester Blueper T-120 130 320 3.23 3.3 16 Polybutene LZV100 205 285 3.19 3.1 17 Alkyl diphenyl ether LA100 102 305 3.20 3.1 18 Polyphenyl ether S-3230 410 285 3.16 3.1 19 Fluoro-oil Fomblin Y45 210 295 3.47 3.3 20 Mineral oil + Diester 60 320 3.20 3.4 21 Polyol ester + 256 295 3.24 3.3 Trimellitic acid ester 22 Alkyl diphenyl ether + 116 323 3.22 3.2 Polyol ester 23 Polyol ester + 396 278 3.21 3.2 Polyphenyl ether

[0093] With the aid of decaglyceryl pentaoleate, there could be obtained grease which were high in both the thermal conductivity and the liquation consistency and which were satisfactory in its thermal conductive property and its dispense property. As can be seen from the results, the diffusion width of the base oil due to bleeding is small, and it is apparent that the surfactant serves to control the isolation of the base oil from the grease regardless the kind of the base oil.

Comparative Examples 11 to 23

[0094] For the comparison purpose with Examples 11 to 23, there were obtained respective grease blended with no nonionic surfactant. Measurements results are as shown in Table 4. TABLE 4 Com- parative Viscosity Thernal Exam- Base oil of base oil Liquation conduc- Diffusion ple (No (mm²/s, at consistency tivity width No. Surfactant) Product Name 40° C.) (at 25° C.) (W/m · K) (mm) 11 Mineral oil N-500 94 Grease formation impossible 12 Diester Adekasin 2050 26 13 Poly-α-olefin SHC230 209 14 Polyol ester Blueper H-450 383 190 2.64 4.3 15 Trimellitic acid ester Blueper T-120 130 Grease formation impossible 16 Polybutene LV100 205 195 2.31 4.7 17 Alkyl diphenyl ether LA100 102 Grease formation impossible 18 Polyphenyl ether S-3230 410 195 2.41 4.6 19 Fluoro-oil Fomblin Y45 210 276 3.21 7.6 20 Mineral oil + Diester — 60 Grease formation impossible 21 Polyol ester + — 256 153 2.11 4.0 Trimellitic acid ester 22 Alkyl diphenyl ether + — 116 Grease formation impossible Polyol ester 23 Polyol ester + — 396 183 2.45 4.8 Polyphenyl ether

[0095] In Comparative Examples 11 to 23, it is difficult to attain a grease formation depending upon the kind of the base oil, and even in the case where the grease formation can be attained, the liquation consistency and the thermal conductivity are low, and therefore neither a satisfactory dispense property nor a high thermal conductivity is attained. In addition, the diffusion width of the base oil due to bleeding is larger than those in Examples 11 to 23, and the base oil is easier to be isolated from the grease than those in Examples 11 to 23.

[0096] In FIG. 3, there is shown a dispersion model of the inorganic powder in the case where the surfactant is added. In FIG. 4, there is shown a dispersion model of the inorganic powder in the case where no surfactant is added.

[0097] From the dispersion model shown in FIG. 3, the fine particles 9 easily enter the voids among the coarse particles 8 with the aid of the surfactant, and as a result, a high filler content of the inorganic powder can be attained. Further, flow of the particles becomes smooth, and therefore a high liquation consistency is attained, in other words, there can be obtained a soft grease. Furthermore, a large quantity of the fine particles 9 enters the voids among the coarse particles 8, and as a result, a mutual contact surface area of the particles increases to decrease the thermal resistance among the particles, whereby there can be obtained a highly thermal conductive grease.

[0098] A most of the base oil is held in the void portions among the particles by a capillary phenomenon. A fine void portions increase with the aid of an addition of the surfactant, and the base oil is held in the resulting fine void portions. As a result, the diffusion width of the base oil due to bleeding of the base oil is decreased, in other words, the isolation of the base oil can be controlled.

[0099] In the dispersion model shown in FIG. 4, wherein no surfactant is added, it is difficult that the fine particles 9 enter the voids among the coarse particles 8. As a result, there are left many voids among the powder particles, and a mutual contact surface area of the particles is decreased to increase the thermal resistance among the particles, thereby decreasing the thermal conductivity of the grease. The particles are difficult to flow and therefore the liquation of consistency becomes small, in other words, the grease becomes hard. Further, the void portions among the particles are larger in comparison with the case where the surfactant is used, and therefore the base oil cannot be held in the void portions and easily bleeds out.

Examples 24 to 62

[0100] Using materials mentioned below, thermal conductive grease compositions were obtained, provided that the base oils different in viscosity (47.0 mm²/s and 400 mm²/s) were used and a ratio of an average particle size of coarse particles Pl and that of fine particles Ps, Pl/Ps, was varied within a range of from ⅓ (one third) to {fraction (1/54)} (one fifty-fourth). The thermal conductivity and liquation consistency thereof were measured. The filler content of the inorganic powder was varied within a range of from 75 to 89% by volume.

[0101] (1) Nonionic surfactant:decaglyceryl pentaoleate, 1% by weight based on the weight of inorganic powder.

[0102] (2) Base oil:poly-α-olefin, viscosity: 47.0 mm²/s or 400 mm²/s.

[0103] (3) Inorganic powder:zinc oxide powder, filler content: 75 to 89% by volume, mixed powder prepared by combining coarse particles having an average particle size of from 5.4 to 16.3 μm and fine particles having an average particle size of from 0.3 to 4.2 μm in a ratio of an average particle size of coarse particles P1 and that of fine particles Ps, P1/Ps, within a range of from ⅓ to {fraction (1/54)} in a blending proportion by volume of coarse particles:fine particles=40 to 100:0 to 60.

[0104] The measurement results are as shown in Table 5 TABLE 5 Combination of fine particles and coarse particles and blending proportion thereof (% by vol.) Average particle size of fine particles Average particle size of coarse (Ps μm) particles (Pl μm) 0.3 0.4 0.6 0.7 1.8 3.8 4.2 5.4 11.6 12.7 13.1 16.3 Range of particle size Example 0.24˜ 0.29˜ 0.17˜ 0.29˜ 0.17˜ 0.41˜ 0.17˜ 4.62˜ 5.50˜ 3.73˜ 7.78˜ No. <2.63 2.31 5.50 3.37 6.54 14.9 9.25 14.9 37.0 37.0 41.0 49.8 24  0 100  25  5 95 26 10 90 27 30 70 28 50 50 29 60 40 30  0 100  31  5 95 32 10 90 33 30 70 34 50 50 35 60 40 36 20 80 37 20 80 38 20 80 39 40 60 40 40 60 41 40 60 42 40 60 43 40 60 44 40 60 45 40 60 46 40 60 47 40 60 48 40 60 49 40 60 50 40 60 51 40 60 52 30 70 53 30 70 54 30 70 55 30 70 56 30 70 57 30 70 58 30 70 59  6 37 57 60  6 37 57 61  6 37 57 62  6 37 57 Filler content of Viscosity of base Liquation Thermal Example mixed powder oil consistency conductivity No. Pl/Ps (vol. %) (mm²/s) (at 25° C.) (W/m · K) 24 — 75 400 290 2.55 25 1/8  285 2.60 26 281 3.00 27 269 3.71 28 241 3.12 29 228 3.05 30 — 277 2.60 31 1/19 290 2.87 32 280 3.03 33 1/19 75 400 255 3.64 34 230 3.43 35 221 3.21 36 1/8  80 47.0 330 3.31 37 1/18 85 233 5.01 38 1/23 240 5.24 39 1/18 80 312 4.47 40 1/7  85 310 4.56 41 1/3  320 4.31 42 1/4  316 4.47 43 1/16 310 5.15 44 1/5  269 5.31 45 1/21 252 5.32 46 1/27 241 5.18 47 1/16 86 220 5.52 48 1/42 85 47.0 Grease formation impossible 49 1/8  215 4.22 50 1/54 Grease formation impossible 51 1/41 205 5.11 52 1/21 245 5.36 53 1/27 250 5.34 54 1/21 87 215 5.77 55 88 200 5.34 56 89 Grease formation impossible 57 1/19 85 246 5.25 58 1/29 240 5.33 59 1/7˜32 264 5.09 60 1/3˜32 256 4.55 61 1/9˜41 260 5.34 62 1/4˜41 255 5.05

[0105] In the case where there are combined coarse particles having an average particle size of from 11.6 to 16.3 μm and fine particles having an average particle size of from 0.4 to 5.4 μm, which is from ⅓ to {fraction (1/41)} times that of the coarse particles, and there are adjusted the blending proportions by volume within a range of from 40 to 90:60 to 10, a thermal conductive grease having a thermal conductivity as high as from 3.0 to 5.77 W/m·K and a satisfactory dispense property can be obtained.

[0106] Further, as can be seen in Examples 59 to 62, a satisfactory dispense property and a high thermal conductivity can be attained by combining two kinds of fine particles. Even when the average particle size of the coarse particles is within a range of from 10 to 20 μm, similar tendency can be obtained. Incidentally, in Examples 46, 48 and 54 wherein fine particles having an average particle size of not more than 0.3 μm were combined, no grease formation could be attained in spite of carrying out the kneading with a three-roll.

Examples 63 to 89 and Comparative Example 24

[0107] Using the materials mentioned below, respective thermal conductive grease were obtained to evaluate the addition effect of various nonionic surfactants in terms of the liquation consistency and thermal conductivity of the grease.

[0108] (1) Nonionic surfactant:various surfactants as shown in Table 6, 1% by weight.

[0109] (2) Base oil:poly-α-olefin, viscosity at 40° C.: 400 mm²/S, 30% by volume.

[0110] (3) Inorganic powder:zinc oxide powder, coarse particles of average particle size; 3.83 μm, filler content: 30% by volume.

[0111] The grease obtained by blending no nonionic surfactant was assigned to be Comparative Example 24. The measurement results are as shown in Table 6. TABLE 6 Liquation Thermal Exam- consis- conduc- ple Classification of tency tivity No. surfactant Chemical name (Commercial name) HLB (at 25° C.) (W/m · K) 63 Sorbitan fatty acid Sorbitan monolaurate (SL-101) 8.6 205 3.15 64 ester Sorbitan palmitate (SP-10) 6.7 245 — 65 Sorbitan monoisostearate (SI-10R) 5.0 350 3.30 66 Sorbitan sesquiisostearate (SI-15R) 4.5 348 3.31 67 Sorbitan monostearate (SS-10) 4.7 269 3.17 67 Sorbitan trioleate (SO-30) 1.7 300 — 68 Sorbitan tritol oil fatty acid ester 1.7 311 3.25 (SR-30) 69 Decaglycerol fatty Glyceryl monoisostearate (MGIS) 4.0 340 — 70 acid ester Decaglyceryl dioleate 10.0 123 3.02 (Decaglyn 2-O) 71 Decaglyceryl distearate 9.5 152 3.01 (Decaglyn 2-S) 72 Decaglyceryl trioleate (Decaglyn 3-O) 7.0 338 — 73 Decaglyceryl pentaisostearate 3.5 362 3.36 (Decaglyn 5-IS) 74 Diglyceryl monoisostearate (DGMIS) 5.5 364 — 75 Decaglyceryl pentaoleate (Decaglyn 5-0) 3.5 370 3.32 76 Propylene glycol, Propylene glycol monostearate (PMS-1C) 3.5 310 — pentaerythritol fatty acid ester 77 Pentaerythritol stearate (PEMS) 2.0 349 3.33 78 Polyoxyethylene Polyoxyethylene sorbit hexastearate 3.0 245 — sorbit fatty acid (GS-6) ester 79 Polyoxyethylene sorbot tetraoleate 8.5 210 3.26 (GO-4) 80 Polyoxyethylene Polyoxyethylene glyceryl monostearate 9.5 195 — glycerol (TMGS-5) fatty acid ester 81 Polyethylene glycerol animal fatty acid 7.0 245 3.27 ester (TGL-0306) 82 Polyethylene glycol Polyoxyethylene monostearate 2.0 310 3.32 fatty acid ester (MYS-1EX) 83 Polyoxyethylene monooleate (MYO- 2) 4.5 275 — 84 Polyethylene glycol distearate 8.5 200 3.11 (CDS-400) 85 Polyoxyethylene Polyoxyethylene stearyl ether (BS-2) 8.0 205 3.05 alkyl ether 86 Polyoxyethylene Polyoxyethylene nonylphenyl ether 4.5 241 3.21 phenyl ether (NP-2) 87 Polyoxyethylene octylphenyl ether 6.0 354 — (OP-3) 88 Polyoxyethylene Polyoxyethylene castor oil (CO-3) 3.0 260 3.26 castor oil, 89 hardened castor oil Polyoxyethylene hardened castor oil 6.0 223 — (HCO-5) Comp. — None — 32 3.11 Ex. 24

[0112] As is clear from the results shown in Table 6, the nonionic surfactant serves to improve dispersibility of the zinc oxide powder. When the HLB value representing a balance of hydrophilic property and lipophilic property is not more than 9, the effect is remarkable, so that the liquation consistency becomes not less than 200 (the grease being greatly softened) to attain a high filler content of the powder. For that reason, the thermal conductivity can be remarkably improved.

Examples 90 to 117 and Comparative Example 25

[0113] Using the materials mentioned below, respective thermal conductive grease were obtained to evaluate the addition effect of various nonionic surfactants in terms of the liquation consistency and thermal conductivity of the grease.

[0114] (1) Nonionic surfactant:those shown in Table 7, 1% by weight based on the weight of the inorganic powder.

[0115] (2) Base oil:poly-α-olefin, viscosity at 40° C.: 400 mm²/s, 30% by volume.

[0116] (3) Inorganic powder:aluminum nitride powder, average particle size: 13.3 μm, filler content: 70% by volume.

[0117] The grease obtained by blending no nonionic surfactant was assigned to be Comparative Example 25. The measurement results are as shown in Table 7. Various nonionic surfactants shown in Table 7 are the same as those shown in Table 6. TABLE 7 Liquation Thermal Exam- consis- conduc- ple Classification tency tivity No. of surfactant Chemical name (Commercial name) HLB (at 25° C.) (W/m · K) 90 Sorbitan fatty Sorbitan monolaurate (SL-101) 8.6 219 3.21 91 acid ester Sorbitan palmitate (SP-10) 6.7 212 — 92 Sorbitan monoisostearate (SI-10R) 5.0 375 3.35 93 Sorbitan sesquiisostearate (SI-15R) 4.5 400 3.33 94 Sorbitan monostearate (SS-10) 4.7 209 3.19 95 Sorbitan trioleate (SO-30) 1.7 280 — 96 Decaglycerol Sorbitan tritol oil fatty acid ester 1.7 314 3.28 fatty acid ester (SR-30) 97 Glyceryl monoisostearate (MGIS) 4.0 300 — 98 Decaglyceryl dioleate (Decaglyn 2-O) 10.0 135 3.10 99 Decaglyceryl distearate (Decaglyn 2-S) 9.5 175 3.16 100 Decaglyceryl trioleate (Decaglyn 3-O) 7.0 364 — 101 Decaglyceryl pentaisostearate 3.5 385 3.29 (Decaglyn 5-IS) 102 Diglyceryl monoisostearate (DGMIS) 5.5 390 — 103 Decaglyceryl pentaoleate (Decaglyn 5-O) 3.5 380 3.36 104 Propylene Propylene glycol monostearate 3.5 378 — glycol, (PMS-1C) 105 pentaerythritol Pentaerythritol stearate (PEMS) 2.0 369 3.38 fatty acid ester 106 Polyoxyethylene Polyoxyethylene sorbit hexastearate 3.0 233 — sorbit fatty (GS-6) 107 acid ester Polyoxyethylene sorbot tetraoleate 8.5 229 3.36 (GO-4) 108 Polyoxyethylene Polyoxyethylene glyceryl monostearate 9.5 187 — glycerol fatty (TMGS-5) 109 acid ester Polyoxyethylene glycerol animal fatty 7.0 221 3.29 acid ester (TGL-0306) 110 Polyethylene Polyoxyethylene monostearate 2.0 400 3.34 glycol fatty (MYS-1EX) 111 acid ester Polyoxyethylene monooleate (MYO-2) 4.5 410 — 112 Polyethylene glycol distearate 8.5 390 3.31 (CDS-400) 113 Polyoxyethylene Polyoxyethylene stearyl ether (BS-2) 8.0 385 3.25 alkyl ether 114 Polyoxyethylene Polyoxyethylene nonylphenyl 4.5 379 — phenyl ether ether (NP-2) 115 Polyoxyethylene octylphenyl ether 6.0 386 3.28 (OP-3) 116 Polyoxyethylene Polyoxyethylene castor oil (CO-3) 3.0 378 — castor oil, 117 hardened castor Polyoxyethylene hardened castor oil 6.0 376 3.35 oil (HCO-5) Comp. None — 55 3.22 Ex. 25

[0118] As is clear from the results shown in Table 7, the nonionic surfactants in accordance with the present invention serves to increase the liquation consistency even in the case of using aluminum nitride powder like in the results of Examples 62 to 84. Also like in Examples 62 to 84, when the HLB value is not more than 9, a high filler content of the aluminum nitride powder can be attained to improve the thermal conductivity remarkably.

[0119] However, since the grease of Examples 63 to 89 (Table 6) and those of Examples 90 to 117 (Table 7) were obtained using the inorganic powder having one kind of the average particle size, those grease exhibit the liquation consistency almost equal to that of the grease shown in Table 1, Table 5 and Table 9 which is mentioned below, while those grease exhibit thermal conductivity of not more than 3.4, which is somewhat inferior to those obtained using the inorganic powder having two kinds of the average particle size.

Examples 118 to 123

[0120] Using the materials mentioned below, respective thermal conductive grease were obtained to study the addition effect of the nonionic surfactant. The measurement results are as shown in Table 8.

[0121] (1) Nonionic surfactant:those shown in Table 8, blending amounts shown in Table 8 (% by weight).

[0122] (2) Base oil:poly-α-olefin, viscosity at 40° C.:400 mm²/s, 20% by volume.

[0123] (3) Inorganic powder:aluminum nitride power, filler content: 80% by volume, mixed powder prepared by combining coarse particles having an average particle size of 12.7 μm and fine particles having an average particle size of 0.7 μm in a blending proportion by volume of coarse particles:fine particles=60:40. TABLE 8 Liquation consistency Exam- Classification Blending proportion based on the weight of mixed ple type/Chemical name powder of zinc oxide (% by wt.) No. (Commercial name) 0 0.1 0.2 0.5 1.0 1.5 2.0 2.5 118 Sorbitane fatty acid ester 55 142 230 295 330 331 330 315 type/Sorbitane trioleate (3.04) (3.64) (4.44) (4.39) (4.40) (4.41) (SO-30) 119 Decaglycerol fatty acid ester 163 250 313 325 322 325 330 type/Decaglyceryl pentaoleate (3.55) (4.49) (4.45) (4.46) (4.46) (Decaglyn 5-O) 120 Polyoxyethylene sorbit fatty 145 220 281 348 355 356 320 acid ester type/ (3.46) (4.34) (4.48) (4.49) (4.50) Polyoxyethylene sorbit hexastearate (GS-6) 121 Polyoxyethylene alkyl ether 139 224 279 317 330 330 314 type/Polyoxyethylene oleyl (3.36) (4.33) (4.39) (4.40) (4.43) ether (BO-2) 122 Polyethylene glycol fatty acid 106 201 237 253 270 271 270 ester type/Polyoxyethylene (3.65) (4.36) (4.41) (4.40) (4.42) monooleate (MYO-2) 123 Polyoxyethylene hardened  90 200 239 250 290 285 275 castor oil type/ (3.49) (4.37) (4.40) (4.43) (4.43) Polyoxyethylene hardened castor oil (HCO-5)

[0124] As can be seen from the results shown in Table 8, the addition effect can be obtained when the blending amount of the nonionic surfactant is not less than 0.2% by weight. Whereas, when not more than 0.1% by weight, the liquation consistency is less than 200, which means a poor addition effect to cause a problem about its dispense property.

Examples 124 to 140

[0125] Using the materials mentioned below, respective thermal conductive grease were obtained to study the effect of combination of the inorganic powder. The measurement results are as shown in Table 9.

[0126] (1) Nonionic surfactant:decaglyceryl pentaoleate, 1% by weight based on the weight of the inorganic powder.

[0127] (2) Base oil:poly-α-olefin, viscosity at 40° C.: 47 mm²/s, 20% by volume.

[0128] (3) Inorganic powder:combination and blending proportion as shown in Table 9. TABLE 9 Filler Combination of powders and blending proportion content thereof (%) of Liquation Thermal Exam- Aluminum Aluminum Titanium Boron mixed consis- conduc- ple Zinc oxide nitride Magnesium oxide oxide oxide nitride powder tency tivity No. (0.65 μm) (12.6 μm) (0.65 μm) (13.3 μm) (0.65 μm) (13.5 μm) (1.0 μm) (0.45 μm) (6.97 μm) (vol. %) (at 25° C.) (W/m · K) 124 40 60 80 330 3.85 125 40 60 315 3.50 126 60 40 310 4.15 127 60 40 300 4.20 128 60 40 295 4.35 129 40 60 328 3.86 130 60 40 330 3.75 131 60 40 320 3.88 132 40 60 310 3.57 133 40 60 305 3.86 134 60 40 300 3.68 135 40 60 295 4.12 136 40 60 296 4.33 137 40 60 295 4.61 138 60 40 287 4.11 139 60 40 296 4.36 140 60 40 288 4.13

[0129] There were obtained highly thermal conductive grease having a thermal conductivity as high as 3.68 to 4.35 W/m·K, and a liquation consistency of 300 to 330 to exhibit a satisfactory dispense property. Considering such liquation consistency, it is possible to attain a higher filler content of the mixed powder, thereby further improving thermal conductivity.

Examples 141 to 143

[0130] A cooling device shown in FIG. 5 was used. Each thermal conductive grease 7 obtained in Examples 41, 45 and 137 was filled between a radiating plate 5 of an aluminum-made radiator equipped with a fin 4 (6 cm×6 cm) and a 80W exothermic body 6 (5×5 cm), whose surface had been processed to have a surface coarse (Ra) of 0.1 μm.

[0131] A grease thickness was adjusted to 0.23 mm. A temperature difference between a neighboring temperature (1 mm depth from the grease-adhering surface) of a grease contact surface in the exothermic body 6 and that (1 mm depth from the grease-adhering surface) of a grease contact surface in the radiating body 5 was measured to measure a thermal resistance (° C./W) of the grease layer. Further, the cooling device was allowed to stand in a thermostat of 100° C. for 50 hours to study the isolation state of the base oil and flow state (retention property) of the grease. The results are as shown in Table 10.

[0132] The cooling device applied with any of the grease obtained in Examples 141 to 143 was found to have a thermal resistance of from 0.096 to 0.103° C./W, namely found to exhibit a satisfactory cooling performance. There was observed no oil diffusion due to oil isolation. In addition, there was observed little flow of the grease and therefore the grease exhibited a satisfactory retention property. In conclusion, significance of the grease was confirmed.

Comparative Example 26

[0133] Using the materials mentioned below without adding any surfactant, thermal conductive grease was obtained, and applied to the cooling device shown in FIG. 5 in a manner similar to that of Example 141. The measurement results are as shown in Table 10. TABLE 10 Com- Com- Ex- Ex- Ex- parative parative ample ample ample Example Example Item 141 142 143 26 27 Liquation 252 320 295 310 275 consistency Thermal 0.096 0.103 0.098 0.125 0.121 resistance (° C./W) Bleeding 1.0 1.3 1.2 3.3 4.3 degree (mm) Flow of None None None 2.0 3.2 grease (mm)

[0134] (1) Base oil:poly-α-olefin oil (SHC 230, manufactured by Mobil Petroleum Ltd.), viscosity at 40° C.: 209 mm²/s, 10% by weight.

[0135] (2) Inorganic powder:mixed powder of 81% by weight of synthetic diamond particles having an average particle size of 2.5 μm and 9% by weight of zinc oxide particles having an average particle size of 0.2 μm, blending proportion of the zinc oxide=10% by volume based on the volume of the whole inorganic powder.

Comparative Example 27

[0136] Using the materials mentioned below without adding any surfactant, thermal conductive grease was obtained, and applied to the cooling device shown in FIG. 5 in a manner similar to that of Example 141. The measurement results are as shown in Table 10.

[0137] (1) Base oil:fluoro-oil (Demnum S-200, manufactured by Daikin Industries Ltd.), viscosity at 40° C.: 210 mm²/s, 10% by weight.

[0138] (2) Inorganic powder:mixed powder of 72% by weight of synthetic diamond particles having an average particle size of 2.0 μm and 18% by weight of boron nitride particles having an average particle size of 0.3 μm.

[0139] The grease obtained in Comparative Examples 26 and 27 are found to have a liquation consistency similar to that of those obtained in Examples 141 to 143, the thermal conductivity thereof is found to be larger as compared thereto, and the bleeding width is found to be remarkably larger. In addition, flow of the grease can be observed, and therefore it can be said that the both grease are inferior to those of Examples 141 to 143 in performance as the thermal conductive grease to be applied to a cooling device.

Advantageous Effect of the Invention

[0140] The thermal conductive grease composition in accordance with the present invention can attain a thermal conductivity of from 3.0 to 5.5 W/m·K and a liquation consistency of from 200 to 400 at the same time, namely both a high thermal conductivity and a satisfactory dispense property. Further, by using the thermal conductive grease composition in accordance with the present invention, heat generated in electric and electronic components can be effectively removed, and therefore it is possible to increase reliability of components for electric and electronic apparatus, and make a cooling device compact.

0 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 21 <210> SEQ ID NO 1 <211> LENGTH: 1839 <212> TYPE: DNA <213> ORGANISM: Mus musculus <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (471)..(1748) <221> NAME/KEY: sig_peptide <222> LOCATION: (471)..(530) <400> SEQUENCE: 1 cctgccgagg cgtgcacagc ggcagcgctc aacctccccc gcgccgccac cgagggtctt 60 gtcgccccac cgcgccccag acccgcgccg gaccccgcgc cgccgcgccg ccgccagcca 120 gcgccacagg gacactgcac cccggtgacc gcaccccgca gatcccggtt ctctagctag 180 caccttctcc ctctctgcca tagccttttt cttcatttcc ccaactaatt tctctctctc 240 tctctctctc tctctctctc tctcactcac tctctctctc ttctcctcgt cccctcccca 300 ccgtcctctc atcctcacct tagacctctc ctgtccttgg ctcctcttca tctttgcttt 360 tccgactcct caagcagcgg tcctacttgg tcctctgagg acttacttgt gtccttatct 420 cactttctcc cggctcatcc cggggttgtc tgaccttggg acaaggaagg atg gtt 476 Met Val 1 ccc ggg gtg agg atc atc ccc tct ttg ctg gga ctc gtg atg ttc tgg 524 Pro Gly Val Arg Ile Ile Pro Ser Leu Leu Gly Leu Val Met Phe Trp 5 10 15 ctc ccg ttg gac tcg caa gca cta tcc cgc tcg ggc aaa gtc tgc ctt 572 Leu Pro Leu Asp Ser Gln Ala Leu Ser Arg Ser Gly Lys Val Cys Leu 20 25 30 ttc ggt gaa aag ata tat acc ccc ggc cag agc tgg cac ccc tac ttg 620 Phe Gly Glu Lys Ile Tyr Thr Pro Gly Gln Ser Trp His Pro Tyr Leu 35 40 45 50 gaa cca caa ggc acg ata tac tgc gtg cgc tgt acc tgc tct gag aat 668 Glu Pro Gln Gly Thr Ile Tyr Cys Val Arg Cys Thr Cys Ser Glu Asn 55 60 65 gga cat gtg aat tgt tac cgc ctc cgc tgc cca ccc ctt cac tgc tca 716 Gly His Val Asn Cys Tyr Arg Leu Arg Cys Pro Pro Leu His Cys Ser 70 75 80 cag cct gtg atg gag cca cag caa tgc tgt ccc agg tgt gtg gat cct 764 Gln Pro Val Met Glu Pro Gln Gln Cys Cys Pro Arg Cys Val Asp Pro 85 90 95 cat gtc ccc tct ggc ctc cga gtt ccc cta aag tcc tgc cag ctc aat 812 His Val Pro Ser Gly Leu Arg Val Pro Leu Lys Ser Cys Gln Leu Asn 100 105 110 gag acc aca tac caa cat gga gag atc ttc agt gcc cag gag ctg ttc 860 Glu Thr Thr Tyr Gln His Gly Glu Ile Phe Ser Ala Gln Glu Leu Phe 115 120 125 130 cct gcc cgc ctg tcc aac cag tgt gtc ctg tgt agc tgt att gaa ggc 908 Pro Ala Arg Leu Ser Asn Gln Cys Val Leu Cys Ser Cys Ile Glu Gly 135 140 145 cac act tac tgt ggt ctc atg acc tgt cct gaa ccc agc tgc ccc acc 956 His Thr Tyr Cys Gly Leu Met Thr Cys Pro Glu Pro Ser Cys Pro Thr 150 155 160 aca ctc cct ctg cct gat tcc tgc tgt cag acc tgc aaa gac agg aca 1004 Thr Leu Pro Leu Pro Asp Ser Cys Cys Gln Thr Cys Lys Asp Arg Thr 165 170 175 act gag agt tcc aca gaa gaa aac ttg aca cag ctg cag cat gga gag 1052 Thr Glu Ser Ser Thr Glu Glu Asn Leu Thr Gln Leu Gln His Gly Glu 180 185 190 aga cat tcc cag gat cca tgc tcg gag agg aga ggc ccc agc acg cca 1100 Arg His Ser Gln Asp Pro Cys Ser Glu Arg Arg Gly Pro Ser Thr Pro 195 200 205 210 gcc ccc acc agc ctc agc tcc cct ctg ggc ttc atc cct cgc cac ttc 1148 Ala Pro Thr Ser Leu Ser Ser Pro Leu Gly Phe Ile Pro Arg His Phe 215 220 225 cag tca gta gga atg ggc agc aca acc atc aag att atc ttg aag gag 1196 Gln Ser Val Gly Met Gly Ser Thr Thr Ile Lys Ile Ile Leu Lys Glu 230 235 240 aaa cat aaa aaa gct tgc aca cac aat ggg aag aca tac tcc cat ggg 1244 Lys His Lys Lys Ala Cys Thr His Asn Gly Lys Thr Tyr Ser His Gly 245 250 255 gag gtg tgg cac ccc act gtg ctc tcc ttt ggc ccc atg ccc tgc atc 1292 Glu Val Trp His Pro Thr Val Leu Ser Phe Gly Pro Met Pro Cys Ile 260 265 270 ctg tgc aca tgt att gat ggc tac cag gac tgc cac cgt gtg acc tgc 1340 Leu Cys Thr Cys Ile Asp Gly Tyr Gln Asp Cys His Arg Val Thr Cys 275 280 285 290 ccc acc caa tat ccc tgc agt caa ccc aag aaa gtg gct ggg aag tgc 1388 Pro Thr Gln Tyr Pro Cys Ser Gln Pro Lys Lys Val Ala Gly Lys Cys 295 300 305 tgc aag atc tgc cca gag gac gag gcg gaa gat gac cac agt gag gtc 1436 Cys Lys Ile Cys Pro Glu Asp Glu Ala Glu Asp Asp His Ser Glu Val 310 315 320 att tcc acc cgg tgt ccc aag gta cca ggc cag ttc cag gtg tac acg 1484 Ile Ser Thr Arg Cys Pro Lys Val Pro Gly Gln Phe Gln Val Tyr Thr 325 330 335 ttg gca tct cca agc cca gac agc cta cac cgc ttt gtc ctg gag cat 1532 Leu Ala Ser Pro Ser Pro Asp Ser Leu His Arg Phe Val Leu Glu His 340 345 350 gaa gcc tct gac cag gta gag atg tac att tgg aag ctg gtg aaa gga 1580 Glu Ala Ser Asp Gln Val Glu Met Tyr Ile Trp Lys Leu Val Lys Gly 355 360 365 370 atc tac cac ttg gtt cag atc aag aga gtc agg aag caa gat ttc cag 1628 Ile Tyr His Leu Val Gln Ile Lys Arg Val Arg Lys Gln Asp Phe Gln 375 380 385 aaa gag gct cag aac ttc cgg ctg ctc acc ggc acc cat gaa ggt tac 1676 Lys Glu Ala Gln Asn Phe Arg Leu Leu Thr Gly Thr His Glu Gly Tyr 390 395 400 tgg acc gtc ttc cta gcc cag act cca gag ctg aaa gtt aca gcc agc 1724 Trp Thr Val Phe Leu Ala Gln Thr Pro Glu Leu Lys Val Thr Ala Ser 405 410 415 cca gac aaa gtg acc aag aca tta tagcaaggac ctaaagagtt gcagatacga 1778 Pro Asp Lys Val Thr Lys Thr Leu 420 425 gttttattgg ttttgttatt atatattaat aaagaagtcg cattaccctc tcccccccac 1838 t 1839 <210> SEQ ID NO 2 <211> LENGTH: 426 <212> TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 2 Met Val Pro Gly Val Arg Ile Ile Pro Ser Leu Leu Gly Leu Val Met 1 5 10 15 Phe Trp Leu Pro Leu Asp Ser Gln Ala Leu Ser Arg Ser Gly Lys Val 20 25 30 Cys Leu Phe Gly Glu Lys Ile Tyr Thr Pro Gly Gln Ser Trp His Pro 35 40 45 Tyr Leu Glu Pro Gln Gly Thr Ile Tyr Cys Val Arg Cys Thr Cys Ser 50 55 60 Glu Asn Gly His Val Asn Cys Tyr Arg Leu Arg Cys Pro Pro Leu His 65 70 75 80 Cys Ser Gln Pro Val Met Glu Pro Gln Gln Cys Cys Pro Arg Cys Val 85 90 95 Asp Pro His Val Pro Ser Gly Leu Arg Val Pro Leu Lys Ser Cys Gln 100 105 110 Leu Asn Glu Thr Thr Tyr Gln His Gly Glu Ile Phe Ser Ala Gln Glu 115 120 125 Leu Phe Pro Ala Arg Leu Ser Asn Gln Cys Val Leu Cys Ser Cys Ile 130 135 140 Glu Gly His Thr Tyr Cys Gly Leu Met Thr Cys Pro Glu Pro Ser Cys 145 150 155 160 Pro Thr Thr Leu Pro Leu Pro Asp Ser Cys Cys Gln Thr Cys Lys Asp 165 170 175 Arg Thr Thr Glu Ser Ser Thr Glu Glu Asn Leu Thr Gln Leu Gln His 180 185 190 Gly Glu Arg His Ser Gln Asp Pro Cys Ser Glu Arg Arg Gly Pro Ser 195 200 205 Thr Pro Ala Pro Thr Ser Leu Ser Ser Pro Leu Gly Phe Ile Pro Arg 210 215 220 His Phe Gln Ser Val Gly Met Gly Ser Thr Thr Ile Lys Ile Ile Leu 225 230 235 240 Lys Glu Lys His Lys Lys Ala Cys Thr His Asn Gly Lys Thr Tyr Ser 245 250 255 His Gly Glu Val Trp His Pro Thr Val Leu Ser Phe Gly Pro Met Pro 260 265 270 Cys Ile Leu Cys Thr Cys Ile Asp Gly Tyr Gln Asp Cys His Arg Val 275 280 285 Thr Cys Pro Thr Gln Tyr Pro Cys Ser Gln Pro Lys Lys Val Ala Gly 290 295 300 Lys Cys Cys Lys Ile Cys Pro Glu Asp Glu Ala Glu Asp Asp His Ser 305 310 315 320 Glu Val Ile Ser Thr Arg Cys Pro Lys Val Pro Gly Gln Phe Gln Val 325 330 335 Tyr Thr Leu Ala Ser Pro Ser Pro Asp Ser Leu His Arg Phe Val Leu 340 345 350 Glu His Glu Ala Ser Asp Gln Val Glu Met Tyr Ile Trp Lys Leu Val 355 360 365 Lys Gly Ile Tyr His Leu Val Gln Ile Lys Arg Val Arg Lys Gln Asp 370 375 380 Phe Gln Lys Glu Ala Gln Asn Phe Arg Leu Leu Thr Gly Thr His Glu 385 390 395 400 Gly Tyr Trp Thr Val Phe Leu Ala Gln Thr Pro Glu Leu Lys Val Thr 405 410 415 Ala Ser Pro Asp Lys Val Thr Lys Thr Leu 420 425 <210> SEQ ID NO 3 <211> LENGTH: 405 <212> TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 3 Asp Ser Gln Ala Leu Ser Arg Ser Gly Lys Val Cys Leu Phe Gly Glu 1 5 10 15 Lys Ile Tyr Thr Pro Gly Gln Ser Trp His Pro Tyr Leu Glu Pro Gln 20 25 30 Gly Thr Ile Tyr Cys Val Arg Cys Thr Cys Ser Glu Asn Gly His Val 35 40 45 Asn Cys Tyr Arg Leu Arg Cys Pro Pro Leu His Cys Ser Gln Pro Val 50 55 60 Met Glu Pro Gln Gln Cys Cys Pro Arg Cys Val Asp Pro His Val Pro 65 70 75 80 Ser Gly Leu Arg Val Pro Leu Lys Ser Cys Gln Leu Asn Glu Thr Thr 85 90 95 Tyr Gln His Gly Glu Ile Phe Ser Ala Gln Glu Leu Phe Pro Ala Arg 100 105 110 Leu Ser Asn Gln Cys Val Leu Cys Ser Cys Ile Glu Gly His Thr Tyr 115 120 125 Cys Gly Leu Met Thr Cys Pro Glu Pro Ser Cys Pro Thr Thr Leu Pro 130 135 140 Leu Pro Asp Ser Cys Cys Gln Thr Cys Lys Asp Arg Thr Thr Glu Ser 145 150 155 160 Ser Thr Glu Glu Asn Leu Thr Gln Leu Gln His Gly Glu Arg His Ser 165 170 175 Gln Asp Pro Cys Ser Glu Arg Arg Gly Pro Ser Thr Pro Ala Pro Thr 180 185 190 Ser Leu Ser Ser Pro Leu Gly Phe Ile Pro Arg His Phe Gln Ser Val 195 200 205 Gly Met Gly Ser Thr Thr Ile Lys Ile Ile Leu Lys Glu Lys His Lys 210 215 220 Lys Ala Cys Thr His Asn Gly Lys Thr Tyr Ser His Gly Glu Val Trp 225 230 235 240 His Pro Thr Val Leu Ser Phe Gly Pro Met Pro Cys Ile Leu Cys Thr 245 250 255 Cys Ile Asp Gly Tyr Gln Asp Cys His Arg Val Thr Cys Pro Thr Gln 260 265 270 Tyr Pro Cys Ser Gln Pro Lys Lys Val Ala Gly Lys Cys Cys Lys Ile 275 280 285 Cys Pro Glu Asp Glu Ala Glu Asp Asp His Ser Glu Val Ile Ser Thr 290 295 300 Arg Cys Pro Lys Val Pro Gly Gln Phe Gln Val Tyr Thr Leu Ala Ser 305 310 315 320 Pro Ser Pro Asp Ser Leu His Arg Phe Val Leu Glu His Glu Ala Ser 325 330 335 Asp Gln Val Glu Met Tyr Ile Trp Lys Leu Val Lys Gly Ile Tyr His 340 345 350 Leu Val Gln Ile Lys Arg Val Arg Lys Gln Asp Phe Gln Lys Glu Ala 355 360 365 Gln Asn Phe Arg Leu Leu Thr Gly Thr His Glu Gly Tyr Trp Thr Val 370 375 380 Phe Leu Ala Gln Thr Pro Glu Leu Lys Val Thr Ala Ser Pro Asp Lys 385 390 395 400 Val Thr Lys Thr Leu 405 <210> SEQ ID NO 4 <211> LENGTH: 1570 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (184)..(1470) <221> NAME/KEY: sig_peptide <222> LOCATION: (184)..(243) <400> SEQUENCE: 4 agacctccct tcctgccctc ctttcctgcc caccgctgct tcctggccct tctccgaccc 60 cgctctagca gcagacctcc tggggtctgt gggttgatct gtggcccctg tgcctccgtg 120 tccttttcgt ctcccttcct cccgactccg ctcccggacc agcggcctga ccctggggaa 180 agg atg gtt ccc gag gtg agg gtc ctc tcc tcc ttg ctg gga ctc gcg 228 Met Val Pro Glu Val Arg Val Leu Ser Ser Leu Leu Gly Leu Ala 1 5 10 15 ctg ctc tgg ttc ccc ctg gac tcc cac gct cga gcc cgc cca gac atg 276 Leu Leu Trp Phe Pro Leu Asp Ser His Ala Arg Ala Arg Pro Asp Met 20 25 30 ttc tgc ctt ttc cat ggg aag aga tac tcc ccc ggc gag agc tgg cac 324 Phe Cys Leu Phe His Gly Lys Arg Tyr Ser Pro Gly Glu Ser Trp His 35 40 45 ccc tac ttg gag cca caa ggc ctg atg tac tgc ctg cgc tgt acc tgc 372 Pro Tyr Leu Glu Pro Gln Gly Leu Met Tyr Cys Leu Arg Cys Thr Cys 50 55 60 tca gag ggc gcc cat gtg agt tgt tac cgc ctc cac tgt ccg cct gtc 420 Ser Glu Gly Ala His Val Ser Cys Tyr Arg Leu His Cys Pro Pro Val 65 70 75 cac tgc ccc cag cct gtg acg gag cca cag caa tgc tgt ccc aag tgt 468 His Cys Pro Gln Pro Val Thr Glu Pro Gln Gln Cys Cys Pro Lys Cys 80 85 90 95 gtg gaa cct cac act ccc tct gga ctc cgg gcc cca cca aag tcc tgc 516 Val Glu Pro His Thr Pro Ser Gly Leu Arg Ala Pro Pro Lys Ser Cys 100 105 110 cag cac aac ggg acc atg tac caa cac gga gag atc ttc agt gcc cat 564 Gln His Asn Gly Thr Met Tyr Gln His Gly Glu Ile Phe Ser Ala His 115 120 125 gag ctg ttc ccc tcc cgc ctg ccc aac cag tgt gtc ctc tgc agc tgc 612 Glu Leu Phe Pro Ser Arg Leu Pro Asn Gln Cys Val Leu Cys Ser Cys 130 135 140 aca gag ggc cag atc tac tgc ggc ctc aca acc tgc ccc gaa cca ggc 660 Thr Glu Gly Gln Ile Tyr Cys Gly Leu Thr Thr Cys Pro Glu Pro Gly 145 150 155 tgc cca gca ccc ctc ccg ctg cca gac tcc tgc tgc caa gcc tgc aaa 708 Cys Pro Ala Pro Leu Pro Leu Pro Asp Ser Cys Cys Gln Ala Cys Lys 160 165 170 175 gat gag gca agt gag caa tcg gat gaa gag gac agt gtg cag tcg ctc 756 Asp Glu Ala Ser Glu Gln Ser Asp Glu Glu Asp Ser Val Gln Ser Leu 180 185 190 cat ggg gtg aga cat cct cag gat cca tgt tcc agt gat gct ggg aga 804 His Gly Val Arg His Pro Gln Asp Pro Cys Ser Ser Asp Ala Gly Arg 195 200 205 aag aga ggc ccg ggc acc cca gcc ccc act ggc ctc agc gcc cct ctg 852 Lys Arg Gly Pro Gly Thr Pro Ala Pro Thr Gly Leu Ser Ala Pro Leu 210 215 220 agc ttc atc cct cgc cac ttc aga ccc aag gga gca ggc agc aca act 900 Ser Phe Ile Pro Arg His Phe Arg Pro Lys Gly Ala Gly Ser Thr Thr 225 230 235 gtc aag atc gtc ctg aag gag aaa cat aag aaa gcc tgt gtg cat ggc 948 Val Lys Ile Val Leu Lys Glu Lys His Lys Lys Ala Cys Val His Gly 240 245 250 255 ggg aag acg tac tcc cac ggg gag gtg tgg cac ccg gcc ttc cgt gcc 996 Gly Lys Thr Tyr Ser His Gly Glu Val Trp His Pro Ala Phe Arg Ala 260 265 270 ttc ggc ccc ttg ccc tgc atc cta tgc acc tgt gag gat ggc cgc cag 1044 Phe Gly Pro Leu Pro Cys Ile Leu Cys Thr Cys Glu Asp Gly Arg Gln 275 280 285 gac tgc cag cgt gtg acc tgt ccc acc gag tac ccc tgc cgt cac ccc 1092 Asp Cys Gln Arg Val Thr Cys Pro Thr Glu Tyr Pro Cys Arg His Pro 290 295 300 gag aaa gtg gct ggg aag tgc tgc aag att tgc cca gag gac aaa gca 1140 Glu Lys Val Ala Gly Lys Cys Cys Lys Ile Cys Pro Glu Asp Lys Ala 305 310 315 gac cct ggc cac agt gag atc agt tct acc agg tgt ccc aag gca ccg 1188 Asp Pro Gly His Ser Glu Ile Ser Ser Thr Arg Cys Pro Lys Ala Pro 320 325 330 335 ggc cgg gtc ctc gtc cac aca tcg gta tcc cca agc cca gac aac ctg 1236 Gly Arg Val Leu Val His Thr Ser Val Ser Pro Ser Pro Asp Asn Leu 340 345 350 cgt cgc ttt gcc ctg gaa cac gag gcc tcg gac ttg gtg gag atc tac 1284 Arg Arg Phe Ala Leu Glu His Glu Ala Ser Asp Leu Val Glu Ile Tyr 355 360 365 ctc tgg aag ctg gtg aaa gga atc ttc cac ttg act cag atc aag aaa 1332 Leu Trp Lys Leu Val Lys Gly Ile Phe His Leu Thr Gln Ile Lys Lys 370 375 380 gtc agg aag caa gac ttc cag aaa gag gca cag cac ttc cga ctg ctc 1380 Val Arg Lys Gln Asp Phe Gln Lys Glu Ala Gln His Phe Arg Leu Leu 385 390 395 gct ggc ccc cac gaa ggt cac tgg aac gtc ttc cta gcc cag acc ctg 1428 Ala Gly Pro His Glu Gly His Trp Asn Val Phe Leu Ala Gln Thr Leu 400 405 410 415 gag ctg aag gtc acg gcc agt cca gac aaa gtg acc aag aca 1470 Glu Leu Lys Val Thr Ala Ser Pro Asp Lys Val Thr Lys Thr 420 425 taacaaagac ctaacagttg cagatatgag ctgtataatt gttgttatta tatattaata 1530 aataagaagt tgcattaccc tcaaaaaaaa aaaaaaaaaa 1570 <210> SEQ ID NO 5 <211> LENGTH: 429 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 5 Met Val Pro Glu Val Arg Val Leu Ser Ser Leu Leu Gly Leu Ala Leu 1 5 10 15 Leu Trp Phe Pro Leu Asp Ser His Ala Arg Ala Arg Pro Asp Met Phe 20 25 30 Cys Leu Phe His Gly Lys Arg Tyr Ser Pro Gly Glu Ser Trp His Pro 35 40 45 Tyr Leu Glu Pro Gln Gly Leu Met Tyr Cys Leu Arg Cys Thr Cys Ser 50 55 60 Glu Gly Ala His Val Ser Cys Tyr Arg Leu His Cys Pro Pro Val His 65 70 75 80 Cys Pro Gln Pro Val Thr Glu Pro Gln Gln Cys Cys Pro Lys Cys Val 85 90 95 Glu Pro His Thr Pro Ser Gly Leu Arg Ala Pro Pro Lys Ser Cys Gln 100 105 110 His Asn Gly Thr Met Tyr Gln His Gly Glu Ile Phe Ser Ala His Glu 115 120 125 Leu Phe Pro Ser Arg Leu Pro Asn Gln Cys Val Leu Cys Ser Cys Thr 130 135 140 Glu Gly Gln Ile Tyr Cys Gly Leu Thr Thr Cys Pro Glu Pro Gly Cys 145 150 155 160 Pro Ala Pro Leu Pro Leu Pro Asp Ser Cys Cys Gln Ala Cys Lys Asp 165 170 175 Glu Ala Ser Glu Gln Ser Asp Glu Glu Asp Ser Val Gln Ser Leu His 180 185 190 Gly Val Arg His Pro Gln Asp Pro Cys Ser Ser Asp Ala Gly Arg Lys 195 200 205 Arg Gly Pro Gly Thr Pro Ala Pro Thr Gly Leu Ser Ala Pro Leu Ser 210 215 220 Phe Ile Pro Arg His Phe Arg Pro Lys Gly Ala Gly Ser Thr Thr Val 225 230 235 240 Lys Ile Val Leu Lys Glu Lys His Lys Lys Ala Cys Val His Gly Gly 245 250 255 Lys Thr Tyr Ser His Gly Glu Val Trp His Pro Ala Phe Arg Ala Phe 260 265 270 Gly Pro Leu Pro Cys Ile Leu Cys Thr Cys Glu Asp Gly Arg Gln Asp 275 280 285 Cys Gln Arg Val Thr Cys Pro Thr Glu Tyr Pro Cys Arg His Pro Glu 290 295 300 Lys Val Ala Gly Lys Cys Cys Lys Ile Cys Pro Glu Asp Lys Ala Asp 305 310 315 320 Pro Gly His Ser Glu Ile Ser Ser Thr Arg Cys Pro Lys Ala Pro Gly 325 330 335 Arg Val Leu Val His Thr Ser Val Ser Pro Ser Pro Asp Asn Leu Arg 340 345 350 Arg Phe Ala Leu Glu His Glu Ala Ser Asp Leu Val Glu Ile Tyr Leu 355 360 365 Trp Lys Leu Val Lys Gly Ile Phe His Leu Thr Gln Ile Lys Lys Val 370 375 380 Arg Lys Gln Asp Phe Gln Lys Glu Ala Gln His Phe Arg Leu Leu Ala 385 390 395 400 Gly Pro His Glu Gly His Trp Asn Val Phe Leu Ala Gln Thr Leu Glu 405 410 415 Leu Lys Val Thr Ala Ser Pro Asp Lys Val Thr Lys Thr 420 425 <210> SEQ ID NO 6 <211> LENGTH: 408 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 6 Asp Ser His Ala Arg Ala Arg Pro Asp Met Phe Cys Leu Phe His Gly 1 5 10 15 Lys Arg Tyr Ser Pro Gly Glu Ser Trp His Pro Tyr Leu Glu Pro Gln 20 25 30 Gly Leu Met Tyr Cys Leu Arg Cys Thr Cys Ser Glu Gly Ala His Val 35 40 45 Ser Cys Tyr Arg Leu His Cys Pro Pro Val His Cys Pro Gln Pro Val 50 55 60 Thr Glu Pro Gln Gln Cys Cys Pro Lys Cys Val Glu Pro His Thr Pro 65 70 75 80 Ser Gly Leu Arg Ala Pro Pro Lys Ser Cys Gln His Asn Gly Thr Met 85 90 95 Tyr Gln His Gly Glu Ile Phe Ser Ala His Glu Leu Phe Pro Ser Arg 100 105 110 Leu Pro Asn Gln Cys Val Leu Cys Ser Cys Thr Glu Gly Gln Ile Tyr 115 120 125 Cys Gly Leu Thr Thr Cys Pro Glu Pro Gly Cys Pro Ala Pro Leu Pro 130 135 140 Leu Pro Asp Ser Cys Cys Gln Ala Cys Lys Asp Glu Ala Ser Glu Gln 145 150 155 160 Ser Asp Glu Glu Asp Ser Val Gln Ser Leu His Gly Val Arg His Pro 165 170 175 Gln Asp Pro Cys Ser Ser Asp Ala Gly Arg Lys Arg Gly Pro Gly Thr 180 185 190 Pro Ala Pro Thr Gly Leu Ser Ala Pro Leu Ser Phe Ile Pro Arg His 195 200 205 Phe Arg Pro Lys Gly Ala Gly Ser Thr Thr Val Lys Ile Val Leu Lys 210 215 220 Glu Lys His Lys Lys Ala Cys Val His Gly Gly Lys Thr Tyr Ser His 225 230 235 240 Gly Glu Val Trp His Pro Ala Phe Arg Ala Phe Gly Pro Leu Pro Cys 245 250 255 Ile Leu Cys Thr Cys Glu Asp Gly Arg Gln Asp Cys Gln Arg Val Thr 260 265 270 Cys Pro Thr Glu Tyr Pro Cys Arg His Pro Glu Lys Val Ala Gly Lys 275 280 285 Cys Cys Lys Ile Cys Pro Glu Asp Lys Ala Asp Pro Gly His Ser Glu 290 295 300 Ile Ser Ser Thr Arg Cys Pro Lys Ala Pro Gly Arg Val Leu Val His 305 310 315 320 Thr Ser Val Ser Pro Ser Pro Asp Asn Leu Arg Arg Phe Ala Leu Glu 325 330 335 His Glu Ala Ser Asp Leu Val Glu Ile Tyr Leu Trp Lys Leu Val Lys 340 345 350 Gly Ile Phe His Leu Thr Gln Ile Lys Lys Val Arg Lys Gln Asp Phe 355 360 365 Gln Lys Glu Ala Gln His Phe Arg Leu Leu Ala Gly Pro His Glu Gly 370 375 380 His Trp Asn Val Phe Leu Ala Gln Thr Leu Glu Leu Lys Val Thr Ala 385 390 395 400 Ser Pro Asp Lys Val Thr Lys Thr 405 <210> SEQ ID NO 7 <211> LENGTH: 283 <212> TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 7 Asn Gly Glu Ala Ala Thr Ser Pro Met Leu Pro Ala Gly Pro Gly Pro 1 5 10 15 Glu Ala Pro Val Pro Ala Lys His Gly Ser Pro Gly Arg Pro Arg Asp 20 25 30 Pro Asn Thr Cys Phe Phe Glu Gly Gln Gln Arg Pro His Gly Ala Arg 35 40 45 Trp Ala Pro Asn Tyr Asp Pro Leu Cys Ser Leu Cys Ile Cys Gln Arg 50 55 60 Arg Thr Val Ile Cys Asp Pro Val Val Cys Pro Pro Pro Ser Cys Pro 65 70 75 80 His Pro Val Gln Ala Leu Asp Gln Cys Cys Pro Val Cys Pro Glu Lys 85 90 95 Gln Arg Ser Arg Asp Leu Pro Ser Leu Pro Asn Leu Glu Pro Gly Glu 100 105 110 Gly Cys Tyr Phe Asp Gly Asp Arg Ser Trp Arg Ala Ala Gly Thr Arg 115 120 125 Trp His Pro Val Val Pro Pro Phe Gly Leu Ile Lys Cys Ala Val Cys 130 135 140 Thr Cys Lys Gly Ala Thr Gly Glu Val His Cys Glu Lys Val Gln Cys 145 150 155 160 Pro Arg Leu Ala Cys Ala Gln Pro Val Arg Ala Asn Pro Thr Asp Cys 165 170 175 Cys Lys Gln Cys Pro Val Gly Ser Gly Thr Asn Ala Lys Leu Gly Asp 180 185 190 Pro Met Gln Ala Asp Gly Pro Arg Gly Cys Arg Phe Ala Gly Gln Trp 195 200 205 Phe Pro Glu Asn Gln Ser Trp His Pro Ser Val Pro Pro Phe Gly Glu 210 215 220 Met Ser Cys Ile Thr Cys Arg Cys Gly Ala Gly Val Pro His Cys Glu 225 230 235 240 Arg Asp Asp Cys Ser Pro Pro Leu Ser Cys Gly Ser Gly Lys Glu Ser 245 250 255 Arg Cys Cys Ser His Cys Thr Ala Gln Arg Ser Ser Glu Thr Arg Thr 260 265 270 Leu Pro Glu Leu Glu Lys Glu Ala Glu His Ser 275 280 <210> SEQ ID NO 8 <211> LENGTH: 955 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 8 Met Pro Ser Leu Pro Ala Pro Pro Ala Pro Leu Leu Leu Leu Gly Leu 1 5 10 15 Leu Leu Leu Gly Ser Arg Pro Ala Arg Gly Ala Gly Pro Glu Pro Pro 20 25 30 Val Leu Pro Ile Arg Ser Glu Lys Glu Pro Leu Pro Val Arg Gly Ala 35 40 45 Ala Gly Cys Thr Phe Gly Gly Lys Val Tyr Ala Leu Asp Glu Thr Trp 50 55 60 His Pro Asp Leu Gly Glu Pro Phe Gly Val Met Arg Cys Val Leu Cys 65 70 75 80 Ala Cys Glu Ala Pro Gln Trp Gly Arg Arg Thr Arg Gly Pro Gly Arg 85 90 95 Val Ser Cys Lys Asn Ile Lys Pro Glu Cys Pro Thr Pro Ala Cys Gly 100 105 110 Gln Pro Arg Gln Leu Pro Gly His Cys Cys Gln Thr Cys Pro Gln Glu 115 120 125 Arg Ser Ser Ser Glu Arg Gln Pro Ser Gly Leu Ser Phe Glu Tyr Pro 130 135 140 Arg Asp Pro Glu His Arg Ser Tyr Ser Asp Arg Gly Glu Pro Gly Ala 145 150 155 160 Glu Glu Arg Ala Arg Gly Asp Gly His Thr Asp Phe Val Ala Leu Leu 165 170 175 Thr Gly Pro Arg Ser Gln Ala Val Ala Arg Ala Arg Val Ser Leu Leu 180 185 190 Arg Ser Ser Leu Arg Phe Ser Ile Ser Tyr Arg Arg Leu Asp Arg Pro 195 200 205 Thr Arg Ile Arg Phe Ser Asp Ser Asn Gly Ser Val Leu Phe Glu His 210 215 220 Pro Ala Ala Pro Thr Gln Asp Gly Leu Val Cys Gly Val Trp Arg Ala 225 230 235 240 Val Pro Arg Leu Ser Leu Arg Leu Leu Arg Ala Glu Gln Leu His Val 245 250 255 Ala Leu Val Thr Leu Thr His Pro Ser Gly Glu Val Trp Gly Pro Leu 260 265 270 Ile Arg His Arg Ala Leu Ala Ala Glu Thr Phe Ser Ala Ile Leu Thr 275 280 285 Leu Glu Gly Pro Pro Gln Gln Gly Val Gly Gly Ile Thr Leu Leu Thr 290 295 300 Leu Ser Asp Thr Glu Asp Ser Leu His Phe Leu Leu Leu Phe Arg Gly 305 310 315 320 Leu Leu Glu Pro Arg Ser Gly Gly Leu Thr Gln Val Pro Leu Arg Leu 325 330 335 Gln Ile Leu His Gln Gly Gln Leu Leu Arg Glu Leu Gln Ala Asn Val 340 345 350 Ser Ala Gln Glu Pro Gly Phe Ala Glu Val Leu Pro Asn Leu Thr Val 355 360 365 Gln Glu Met Asp Trp Leu Val Leu Gly Glu Leu Gln Met Ala Leu Glu 370 375 380 Trp Ala Gly Arg Pro Gly Leu Arg Ile Ser Gly His Ile Ala Ala Arg 385 390 395 400 Lys Ser Cys Asp Val Leu Gln Ser Val Leu Cys Gly Ala Asp Ala Leu 405 410 415 Ile Pro Val Gln Thr Gly Ala Ala Gly Ser Ala Ser Leu Thr Leu Leu 420 425 430 Gly Asn Gly Ser Leu Ile Tyr Gln Val Gln Val Val Gly Thr Ser Ser 435 440 445 Glu Val Val Ala Met Thr Leu Glu Thr Lys Pro Gln Arg Arg Asp Gln 450 455 460 Arg Thr Val Leu Cys His Met Ala Gly Leu Gln Pro Gly Gly His Thr 465 470 475 480 Ala Val Gly Ile Cys Pro Gly Leu Gly Ala Arg Gly Ala His Met Leu 485 490 495 Leu Gln Asn Glu Leu Phe Leu Asn Val Gly Thr Lys Asp Phe Pro Asp 500 505 510 Gly Glu Leu Arg Gly His Val Ala Ala Leu Pro Tyr Cys Gly His Ser 515 520 525 Ala Arg His Asp Thr Leu Pro Val Pro Leu Ala Gly Ala Leu Val Leu 530 535 540 Pro Pro Val Lys Ser Gln Ala Ala Gly His Ala Trp Leu Ser Leu Asp 545 550 555 560 Thr His Cys His Leu His Tyr Glu Val Leu Leu Ala Gly Leu Gly Gly 565 570 575 Ser Glu Gln Gly Thr Val Thr Ala His Leu Leu Gly Pro Pro Gly Thr 580 585 590 Pro Gly Pro Arg Arg Leu Leu Lys Gly Phe Tyr Gly Ser Glu Ala Gln 595 600 605 Gly Val Val Lys Asp Leu Glu Pro Glu Leu Leu Arg His Leu Ala Lys 610 615 620 Gly Met Ala Ser Leu Leu Ile Thr Thr Lys Gly Ser Pro Arg Gly Glu 625 630 635 640 Leu Arg Gly Gln Val His Ile Ala Asn Gln Cys Glu Val Gly Gly Leu 645 650 655 Arg Leu Glu Ala Ala Gly Ala Glu Gly Val Arg Ala Leu Gly Ala Pro 660 665 670 Asp Thr Ala Ser Ala Ala Pro Pro Val Val Pro Gly Leu Pro Ala Leu 675 680 685 Ala Pro Ala Lys Pro Gly Gly Pro Gly Arg Pro Arg Asp Pro Asn Thr 690 695 700 Cys Phe Phe Glu Gly Gln Gln Arg Pro His Gly Ala Arg Trp Ala Pro 705 710 715 720 Asn Tyr Asp Pro Leu Cys Ser Leu Cys Thr Cys Gln Arg Arg Thr Val 725 730 735 Ile Cys Asp Pro Val Val Cys Pro Pro Pro Ser Cys Pro His Pro Val 740 745 750 Gln Ala Pro Asp Gln Cys Cys Pro Val Cys Pro Glu Lys Gln Asp Val 755 760 765 Arg Asp Leu Pro Gly Leu Pro Arg Ser Arg Asp Pro Gly Glu Gly Cys 770 775 780 Tyr Phe Asp Gly Asp Arg Ser Trp Arg Ala Ala Gly Thr Arg Trp His 785 790 795 800 Pro Val Val Pro Pro Phe Gly Leu Ile Lys Cys Ala Val Cys Thr Cys 805 810 815 Lys Gly Gly Thr Gly Glu Val His Cys Glu Lys Val Gln Cys Pro Arg 820 825 830 Leu Ala Cys Ala Gln Pro Val Arg Val Asn Pro Thr Asp Cys Cys Lys 835 840 845 Gln Cys Pro Val Gly Ser Gly Ala His Pro Gln Leu Gly Asp Pro Met 850 855 860 Gln Ala Asp Gly Pro Arg Gly Cys Arg Phe Ala Gly Gln Trp Phe Pro 865 870 875 880 Glu Ser Gln Ser Trp His Pro Ser Val Pro Pro Phe Gly Glu Met Ser 885 890 895 Cys Ile Thr Cys Arg Cys Gly Ala Gly Val Pro His Cys Glu Arg Asp 900 905 910 Asp Cys Ser Leu Pro Leu Ser Cys Gly Ser Gly Lys Glu Ser Arg Cys 915 920 925 Cys Ser Arg Cys Thr Ala His Arg Arg Pro Ala Pro Glu Thr Arg Thr 930 935 940 Asp Pro Glu Leu Glu Lys Glu Ala Glu Gly Ser 945 950 955 <210> SEQ ID NO 9 <211> LENGTH: 452 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 9 Met Gly Gly Met Lys Tyr Ile Phe Ser Leu Leu Phe Phe Leu Leu Leu 1 5 10 15 Glu Gly Gly Lys Thr Glu Gln Val Lys His Ser Glu Thr Tyr Cys Met 20 25 30 Phe Gln Asp Lys Lys Tyr Arg Val Gly Glu Arg Trp His Pro Tyr Leu 35 40 45 Glu Pro Tyr Gly Leu Val Tyr Cys Val Asn Cys Ile Cys Ser Glu Asn 50 55 60 Gly Asn Val Leu Cys Ser Arg Val Arg Cys Pro Asn Val His Cys Leu 65 70 75 80 Ser Pro Val His Ile Pro His Leu Cys Cys Pro Arg Cys Pro Glu Asp 85 90 95 Ser Leu Pro Pro Val Asn Asn Lys Val Thr Ser Lys Ser Cys Glu Tyr 100 105 110 Asn Gly Thr Thr Tyr Gln His Gly Glu Leu Phe Val Ala Glu Gly Leu 115 120 125 Phe Gln Asn Arg Gln Pro Asn Gln Cys Thr Gln Cys Ser Cys Ser Glu 130 135 140 Gly Asn Val Tyr Cys Gly Leu Lys Thr Cys Pro Lys Leu Thr Cys Ala 145 150 155 160 Phe Pro Val Ser Val Pro Asp Ser Cys Cys Arg Val Cys Arg Gly Asp 165 170 175 Gly Glu Leu Ser Trp Glu His Ser Asp Gly Asp Ile Phe Arg Gln Pro 180 185 190 Ala Asn Arg Glu Ala Arg His Ser Tyr His Arg Ser His Tyr Asp Pro 195 200 205 Pro Pro Ser Arg Gln Ala Gly Gly Leu Ser Arg Phe Pro Gly Ala Arg 210 215 220 Ser His Arg Gly Ala Leu Met Asp Ser Gln Gln Ala Ser Gly Thr Ile 225 230 235 240 Val Gln Ile Val Ile Asn Asn Lys His Lys His Gly Gln Val Cys Val 245 250 255 Ser Asn Gly Lys Thr Tyr Ser His Gly Glu Ser Trp His Pro Asn Leu 260 265 270 Arg Ala Phe Gly Ile Val Glu Cys Val Leu Cys Thr Cys Asn Val Thr 275 280 285 Lys Gln Glu Cys Lys Lys Ile His Cys Pro Asn Arg Tyr Pro Cys Lys 290 295 300 Tyr Pro Gln Lys Ile Asp Gly Lys Cys Cys Lys Val Cys Pro Gly Lys 305 310 315 320 Lys Ala Lys Glu Glu Leu Pro Gly Gln Ser Phe Asp Asn Lys Gly Tyr 325 330 335 Phe Cys Gly Glu Glu Thr Met Pro Val Tyr Glu Ser Val Phe Met Glu 340 345 350 Asp Gly Glu Thr Thr Arg Lys Ile Ala Leu Glu Thr Glu Arg Pro Pro 355 360 365 Gln Val Glu Val His Val Trp Thr Ile Arg Lys Gly Ile Leu Gln His 370 375 380 Phe His Ile Glu Lys Ile Ser Lys Arg Met Phe Glu Glu Leu Pro His 385 390 395 400 Phe Lys Leu Val Thr Arg Thr Thr Leu Ser Gln Trp Lys Ile Phe Thr 405 410 415 Glu Gly Glu Ala Gln Ile Ser Gln Met Cys Ser Ser Arg Val Cys Arg 420 425 430 Thr Glu Leu Glu Asp Leu Val Lys Val Leu Tyr Leu Glu Arg Ser Glu 435 440 445 Lys Gly His Cys 450 <210> SEQ ID NO 10 <211> LENGTH: 11 <212> TYPE: PRT <213> ORGANISM: Human immunodeficiency virus type 1 <400> SEQUENCE: 10 Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 1 5 10 <210> SEQ ID NO 11 <211> LENGTH: 15 <212> TYPE: PRT <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: internalizing domain derived from HIV tat protein <400> SEQUENCE: 11 Gly Gly Gly Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 1 5 10 15 <210> SEQ ID NO 12 <211> LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: oligonucleotide; primer 1605-21 <400> SEQUENCE: 12 aatccgatgc ccacgttgca gta 23 <210> SEQ ID NO 13 <211> LENGTH: 26 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: oligonucleotide; PCR primer 1239-08 <400> SEQUENCE: 13 aaaatcttag accgacgact gtgttt 26 <210> SEQ ID NO 14 <211> LENGTH: 25 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: oligonucleotide; PCR primer <400> SEQUENCE: 14 cgtaaaagat cctgcgctag atgcg 25 <210> SEQ ID NO 15 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: oligonucleotide; PCR primer <400> SEQUENCE: 15 tcctctcatc ctcaccttag 20 <210> SEQ ID NO 16 <211> LENGTH: 22 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: oligonucleotide; PCR primer <400> SEQUENCE: 16 ggagaaagtg agataaggac ac 22 <210> SEQ ID NO 17 <211> LENGTH: 40 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: oligonucleotide; PCR primer 2360-40 <400> SEQUENCE: 17 gctatctaga gccaccatgg ttcccggggt gaggatcatc 40 <210> SEQ ID NO 18 <211> LENGTH: 36 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: oligonucleotide; PCR primer 2360-41 <400> SEQUENCE: 18 gctagtcgac ctataatgtc ttggtcactt tgtctg 36 <210> SEQ ID NO 19 <211> LENGTH: 42 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: oligonucleotide; PCR primer <400> SEQUENCE: 19 gctagcggcc gcgccaccat ggttcccggg gtgaggatca tc 42 <210> SEQ ID NO 20 <211> LENGTH: 36 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: oligonucleotide; PCR primer <400> SEQUENCE: 20 gctagtcgac taatgtcttg gtcactttgt ctgggc 36 <210> SEQ ID NO 21 <211> LENGTH: 17 <212> TYPE: PRT <213> ORGANISM: Mus musculus <400> SEQUENCE: 21 Cys Pro Glu Asp Glu Ala Glu Asp Asp His Ser Glu Val Ile Ser Thr 1 5 10 15 Arg 

What is claimed is:
 1. A highly thermal conductive grease composition which comprises an inorganic powder and a base oil containing a mineral oil or a synthetic oil, wherein the inorganic powder is a mixture of at least two kinds of inorganic powders different from each other in each average particle size, the base oil further contains a surfactant in an amount of from 0.2 to 2.0% by weight based on the weight of the inorganic powder, and a content of the base oil is from 10 to 30% by volume, and a content of the inorganic powder is from 70 to 90% by volume.
 2. The highly thermal conductive grease composition according to claim 1, wherein the content of the inorganic powder φ (% by volume) and a viscosity η (mm²/s) at 40° C. of the base oil are expressed by the following expression (1). Logφ≦−1×10⁻¹⁸×(η−250)⁵+1.9345  (1)
 3. The highly thermal conductive grease composition according to claim 1, wherein the viscosity at 40° C. of the base oil is from 15 to 450 mm²/s, and the base oil comprises at least one member selected from the group consisting of α-olefin oligomers, diesters, polyol esters, trimellitic acid esters, polyphenyl ethers and alkyl phenyl ethers.
 4. The highly thermal conductive grease composition according to claim 1, wherein the inorganic powder is a combination of from 40 to 90% by volume of coarse particles having an average particle size of from 5 to 17 μm and 10 to 60% by volume of fine particles having an average particle size of from one third to one fortieth of that of the coarse particle size, and the inorganic powder comprises at least one member selected from the group consisting of zinc oxide, magnesium oxide, titanium oxide, aluminum nitride, aluminum oxide and boron nitride.
 5. The highly thermal conductive grease composition according to claim 1, wherein a liquation consistency is from 200 to
 400. 6. The highly thermal conductive grease composition according to claim 1, wherein the surfactant is a nonionic surfactant having an HLB value of not more than
 9. 7. A cooling device provided with an electric or electronic component assembled into an apparatus and a cooling body put on a surface of said component, in which the highly thermal conductive grease composition according to any of claims 1 to 6 intervenes between said cooling body and a surface of an exothermic body in said component. 